Assessment of Changes in Clinical and Radiological Parameters in Gingival Pockets After Subgingival Application of 1.2% Lovastatin Gel in Combination With SRP Procedure Compared to SRP and Placebo Gel Application in the Treatment of Periodontal Disease in Generally Healthy Non-smokers and Smokers From Central Europe: a Split-mouth Randomized Controlled Trial.

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of the study is to evaluate how a gel (1.2% lovastatin) applied under the gum improves the results of classic periodontal treatment (SRP-scaling, root planing). The study involves two groups of adults diagnosed with periodontitis: the first group consists of generally healthy individuals who do not smoke tobacco. The second group consists of generally healthy individuals who have been smoking for at least 5 years. Before the study begins, each participant will undergo gum health measurements. Changes in these parameters will be monitored throughout the study. Two teeth will be selected for each participant: * a gel containing the medication will be applied under the gum of one tooth * a gel that looks similar to the medication but does not contain any medicinal substance will be applied under the gum of the second tooth. Before applying the gel, each participant will undergo subgingival cleaning (SRP) to remove any debris that may prevent the medicine from working. The study will last six months. Expected results: * all participants will experience an improvement in the condition of their gums after treatment * the effect of treatment will be better in non-smokers than in smokers * the treatment outcome will be better in the area where the medicated gel was applied compared to areas where the gel without medicinal substances was applied.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 59
Healthy Volunteers: f
View:

• generally healthy patients

• diagnosed periodontal disease (at least one pair of non-adjacent sites with PD≥5 mm or CAL ≥4 mm and vertical bone loss ≥ 3 mm)

• no history of periodontal disease treatment

• no history of antibiotic use in the past 6 months

• an eligible tooth must be alive, with no history of endodontic treatment

• non-smoking (group I) or active smokers (group 2)

Locations
Other Locations
Poland
Pietrzko Dental Clinic
RECRUITING
Bielsko-biala
Contact Information
Primary
Magdalena Pietrzko, DMD
pietrzkoperio@gmail.com
+48604796143
Backup
Rafał Wiench, profesor
rwiench@sum.edu.pl
Time Frame
Start Date: 2025-07-11
Estimated Completion Date: 2026-12
Participants
Target number of participants: 44
Treatments
Experimental: patients generally healthy, non-smokers, diagnosed with periodontal disease
Test side- gingival pocket that meets the inclusion criteria and to which a gel containing 1.2% lovastatin will be assigned in patients generally healthy, non-smokers, diagnosed with periodontitis.
Experimental: Generally healthy patients active smokers with periodontits
Test side- gingival pocket that meets the inclusion criteria and to which a gel containing 1.2% lovastatin will be assigned in patients generally healthy,smokers, diagnosed with periodontitis.
Placebo_comparator: Generally healthy patients, active smokers with periodontits
control side: gingival pocket that meets the inclusion criteria and to which a placebo gel in patients generally healthy, smokers, diagnosed with periodontitis.
Placebo_comparator: patients generally healthy, non-smokers, diagnosed with periodontitis
control side: gingival pocket that meets the inclusion criteria and to which a placebo gel in patients generally healthy, non-smokers, diagnosed with periodontitis.
Related Therapeutic Areas
Sponsors
Leads: Medical University of Silesia

This content was sourced from clinicaltrials.gov