Regenerative Therapy of Intrabony Periodontal Defects Using Bone Substitutes and a Minimally Invasive Nonincised Papilla Surgical Approach - A Randomized Controlled Clinical Trial
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.
• Age ≥ 18 years
• Diagnosis of Stage III periodontitis
• At least one intrabony periodontal defect with probing depth \> 5 mm following completion of non-surgical periodontal therapy
• Full-mouth plaque score (FMPS) \< 20%
• Full-mouth bleeding score (FMBS) \< 20%
• Ability to understand the study procedures and provide written informed consent