Clinical Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients : A Split Mouth Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Biological, Drug, Device
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study is a randomized, controlled, split-mouth clinical trial designed to evaluate and compare the effectiveness of four different subgingival adjuncts used along side standard Scaling and Root Planning (SRP). This protocol is designed to be a standardized therapeutic model. The subgingival adjuncts are standardized, ensuring that the results are not operator dependent and can be replicated across any dental unit. The primary goal of this study is to evaluate the clinical efficacy of three distinct adjunctive strategies: Biological (I-PRF), Antiseptic : Povidone- iodine , Diode-Laser activation, compared to a Saline Control in the initial treatment of stage 2, 3 and stage 4 of the 2018 AAP/EFP periodontal classification.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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Locations
Other Locations
Tunisia
Military Hospital of Instruction of Tunis
RECRUITING
Tunis
Contact Information
Primary
Hela Jegham, DDS - Professor
hela.jegham@yahoo.fr
+21654241521
Backup
hedi chouchene, DDS
chouchanehadi76@gmail.com
+21652042177
Time Frame
Start Date: 2026-05-25
Estimated Completion Date: 2027-05-18
Participants
Target number of participants: 50
Treatments
Experimental: I-PRF
Quadrants randomly assigned to receive I-PRF irrigation after SRP
Experimental: Povidone-Iodine
Quadrants randomly assigned to receive 1% povidone-iodine irrigation after SRP
Experimental: Diode Laser
Quadrants randomly assigned to receive diode laser activation after SRP
Sham_comparator: Saline Control
Quadrants randomly assigned to receive 0.9% saline irrigation after SRP
Related Therapeutic Areas
Sponsors
Leads: Military Hospital of Tunis