Feasibility Testing of a Tai Chi Program for Chemotherapy-Induced Peripheral Neuropathy Treatment (TCT)

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This research is being done to determine whether a 12-week virtual Tai Chi training program, designed to improve balance and small nerve fiber function, is feasible and acceptable among cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 years old and older

• Cancer survivors with no evidence of disease (cancer);

• Completed neurotoxic chemotherapy, i.e., platinum agents, taxanes, vinca alkaloids, and bortezomib, at least three months before enrollment;

• A CIPN diagnosis based on symptom history, loss of deep tendon reflexes, or presence of symmetrical stocking-glove pain, numbness, or paresthesia;

• Answers yes to the following question: Do you feel as though your balance is affected from experiencing CIPN? or Are you afraid of falling as a result of your CIPN?;

• On a stable regimen (no change in past three months) if taking anti-neuropathy or other pain medications;

• Eastern Cooperative Oncology Group (ECOG) Performance Status Scale score ≤ 2

• Willing to adhere to all study-related procedures, including randomization to the Tai Chi or waitlist group, 2 in-person visits to Dana-Farber Cancer Institute (DFCI) (one within 2 weeks of enrollment and one at week 12);

• Willing to adhere to requirement that no new pain medication be taken throughout the study period; and

• Individuals receiving endocrine therapy or targeted/antibody therapy, such as trastuzumab, pertuzumab, or immunotherapy, will be eligible to participate.

Locations
United States
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Contact Information
Primary
Ting Bao, MD
ting_bao@dfci.harvard.edu
857-215-2844
Backup
Natalie Viyaran
natalie_viyaran@dfci.harvard.edu
Time Frame
Start Date: 2026-01-16
Estimated Completion Date: 2026-10-31
Participants
Target number of participants: 21
Treatments
Experimental: Arm A: Tai Chi Treatment Group
14 randomized participants will complete:~* 1 baseline visit session.~* Virtual Tai Chi session 2x weekly (60 minutes per session).~* Independent Tai Chi sessions 3 days a week (60 minutes per session).~* 12 week follow up visit.
No_intervention: Arm B: Waitlist Control Group
7 randomized participants will complete:~* 1 baseline visit session~* Standard CIPN care prescribed by primary care physician/oncologist.~* 12 week follow up visit~* Participants will be offered 24 complimentary, virtual, Tai Chi training sessions over 12 weeks after completion of the 12-week follow-up visit.
Related Therapeutic Areas
Sponsors
Leads: Dana-Farber Cancer Institute

This content was sourced from clinicaltrials.gov