Improving Therapeutic Learning for PTSD
Who is this study for? Adult women with post-traumatic stress disorder
What treatments are being studied? L-DOPA
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The proposed project seeks to demonstrate the engagement of post-exposure dopamine neurotransmission and downstream acute reorganization of dopaminergic resting-state neural networks as a means of increasing consolidation of extinction memories formed during analogue exposure therapy in adult women with PTSD. Participants will include 120 women aged 21-50 with a current diagnosis of PTSD related to physical or sexual assault, English speaking, and medically healthy. Participants will complete the stages of the study across 2-3 days, depending on participant need.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 21
Maximum Age: 50
Healthy Volunteers: t
View:
• Current diagnosis of PTSD where the index traumatic event includes physical or sexual assault
• English speaking
• Medically healthy
Locations
United States
Texas
University of Texas
RECRUITING
Austin
Wisconsin
University of Wisconsin
COMPLETED
Madison
Contact Information
Primary
Rachel Williams
rmwilliams5@wisc.edu
608-262-6375
Time Frame
Start Date: 2021-02-18
Estimated Completion Date: 2023-12
Participants
Target number of participants: 120
Treatments
Experimental: 100 mg L-DOPA
Complete a \~40 min fMRI scan with either hearing their trauma or neutral narrative, ingest a pill (placebo or 100mg L-DOPA) upon leaving the scanner and wait in a waiting room for \~45 minutes, then undergo a 7 min resting-state fMRI scan.Participants return \~24 hours later for Day 2 fMRI, in which they will complete a single \~40-minute fMRI scan while listening to either their trauma or neutral narrative.
Placebo_comparator: Placebo
Complete a \~40 min fMRI scan with either hearing their trauma or neutral narrative, ingest a pill (placebo or 100mg L-DOPA) upon leaving the scanner and wait in a waiting room for \~45 minutes, then undergo a 7 min resting-state fMRI scan.Participants return \~24 hours later for Day 2 fMRI, in which they will complete a single \~40-minute fMRI scan while listening to either their trauma or neutral narrative.
Authors
Related Therapeutic Areas
Sponsors
Leads: University of Wisconsin, Madison
Collaborators: National Institute of Mental Health (NIMH)