Relationship of Exercise Frequency, Intensity, and Fitness to Improved Cognition and Biomarkers in Gerofit Participants

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: t
View:

• All Veterans eligible for VA Gerofit program 65 years and older

• Clearance by PCP to participate in Gerofit exercise program

Locations
United States
California
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
RECRUITING
West Los Angeles
Maryland
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
RECRUITING
Baltimore
Contact Information
Primary
Cathy C Lee, MD
cathy.lee2@va.gov
(310) 268-4110
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2029-03-31
Participants
Target number of participants: 150
Treatments
Active_comparator: Gerofit exercise
Participants enrolled in the Gerofit program
Placebo_comparator: Health education
Participants enrolled in monthly in-person health education sessions which do not include a physical activity/exercise promotion session
Sponsors
Leads: VA Office of Research and Development

This content was sourced from clinicaltrials.gov