Etude Longitudinale En Imagerie Cérébrale, En Neuropsychologie, Et En Psychopathologie, Des Conséquences D'un Événement Traumatique

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after trauma in exposed participants as well as in control non-exposed participants. This project will capitalize on recent evidence showing that healthy participants can prevent unwanted images from entering consciousness using inhibitory control and memory suppression techniques, disrupting traces of the memories in sensory areas of the brain, and weakening their vividness and later reentrance. This process is believed to be affected in Post-traumatic stress disorder (PTSD) which is characterized by anxiety and persistent intrusive memory of the traumatic event with highly distressing contents. This project will thus provide a unique opportunity to observe the online and structural dysfunctions of intrusion control network following a severe psychological trauma and how such process may contribute to recovery and psychopathological dynamics. In addition, the disruption of social cognition and emotional processing following PTSD will also be investigated in relation to disrupted inhibitory control functioning.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: t
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• Participants between 18 and 55 years old.

• Present at the scene of the attacks the evening of 13 November 2015 or inhabitant of one of the neighbourhood affected by the attacks (exposed group), or persons were not in Paris on the evening of the attacks and not residing in Paris and its region (unexposed group).

• Affiliated to the French national health care system

• Have a good knowledge of the French language

• Right-handed

• Body mass less than or equal to 35kg/m2

• Signed written consent form

Locations
Other Locations
France
GIP Cyceron
RECRUITING
Caen
Contact Information
Primary
Pierre Gagnepain, PhD
gagnepain@cyceron.fr
Time Frame
Start Date: 2016-06-13
Estimated Completion Date: 2025-12-08
Participants
Target number of participants: 180
Treatments
Experimental: Exposed group
Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI)
Experimental: unexposed group
Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI)
Related Therapeutic Areas
Sponsors
Leads: Institut National de la Santé Et de la Recherche Médicale, France

This content was sourced from clinicaltrials.gov