Electroretinogram (ERG) as a Potential Biomarker of Serotonin Selective Reuptake Inhibitor (SSRI)-Responsive Posttraumatic Stress Disorder (PTSD): A Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. Previous studies suggest that there is a connection between the brain and the retina, and that the electroretinogram (ERG) may be a valuable biomarker to tell us more about signals in the brain that are related to mental health disorders like PTSD. The goal of this observational study is to examine the ERG waveform in veterans with PTSD before and after a single dose of the selective serotonin reuptake inhibitor (SSRI), sertraline. Sertraline is one of two FDA-approved medications for the treatment of PTSD. The main questions this pilot study aims to answer are: 1. How does sertraline, an SSRI, influence the ERG waveform in veterans with PTSD? 2. Is there a significant correlation between baseline ERG signals and the change in ERG following SSRI treatment? Participants will be asked to: * Undergo ERG recordings before and after a single dose of sertraline. * Provide relevant clinical information related to PTSD symptoms and treatment history. Following the initial study visits, participants will enter an optional open label phase of the study in which qualifying participants who initiate antidepressant treatment through routine clinical care will be invited back for a follow-up ERG recording.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 75
Healthy Volunteers: f
View:

• Veteran of the U.S. Armed Forces

• Current diagnosis of PTSD

Locations
United States
Washington
VA Puget Sound Health Care System
RECRUITING
Seattle
Contact Information
Primary
Katharine J Liang, MD, PhD
katharine.liang@va.gov
(206) 277-6538
Backup
Rebecca C Hendrickson
rebecca.hendrickson@va.gov
206-277-5054
Time Frame
Start Date: 2024-02-12
Estimated Completion Date: 2030-09-01
Participants
Target number of participants: 50
Treatments
Experimental: ERG, all participants
All participants undergo ERG recording before and after a single dose of sertraline 50 mg.
Related Therapeutic Areas
Sponsors
Leads: VA Puget Sound Health Care System

This content was sourced from clinicaltrials.gov