Identifying Clinically Relevant Neural Circuit Mechanisms of Cognitive Control Training for PTSD

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The project will further validate the relationship between working memory and fear extinction using novel computational and multivariate analyses that link to specific PTSD symptoms. If WMT can enhance fear extinction learning, then WMT may be a powerful adjunctive treatment that can enhance exposure therapy outcomes or be leveraged as a stand-alone treatment. This project supports the Department of Veteran Affairs mission of developing viable targets of treatment for Veterans with PTSD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Fluent in English

• Meet current DSM-5 criteria for Posttraumatic Stress Disorder

• Are willing to attend 8 total remote sessions of working memory training over course of four weeks

• Are willing to attend MRI scans pre and post working memory training

• 4-week stability on pharmacological and psychosocial treatments

Locations
United States
California
VA San Diego Healthcare System, San Diego, CA
RECRUITING
San Diego
Contact Information
Primary
Daniel M Stout, PhD
Daniel.Stout@va.gov
(858) 642-3944
Time Frame
Start Date: 2024-10-01
Estimated Completion Date: 2028-09-30
Participants
Target number of participants: 120
Treatments
Experimental: Working Memory Training
Computer-administered working memory training program. WMT is a modified working memory capacity task designed to train working memory functioning. WMT is designed to contain high interference across trials and is adaptive to performance. As participants improve working memory, the task becomes more difficult.
Sham_comparator: Sham Training
The Sham condition requires participants to complete a similar computer task for the same length of time. The Sham Training is a modified working memory capacity task designed to place less demands on working memory.
Related Therapeutic Areas
Sponsors
Leads: VA Office of Research and Development

This content was sourced from clinicaltrials.gov

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