Post-Traumatic Stress Disorder (PTSD) Clinical Trials

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Evaluating the Efficacy of the Mental Gym® Biofeedback-Based Intervention for Combat Veterans Diagnosed With PTSD: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized controlled trial (RCT) will evaluate the effectiveness of a digital biofeedback-based intervention (Mental Gym®) designed to reduce Posttraumatic Stress Disorder (PTSD) symptoms and improve mental health. The intervention combines daily HRV biofeedback exercises using a wearable device (Garmin watch), a dedicated mobile application, and weekly group guidance sessions. A delayed-intervention control group design will be used. To account for expected attrition and ensure a final sample of 60 participants, approximately 80 subjects will be recruited. Physiological and self-report data will be collected pre- and post-intervention, weekly during the intervention, and at follow-ups (3 months post-intervention). The study population consists of combat veterans diagnosed with PTSD.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:

• Sex: Male

• Age: 18 Years and older.

• Diagnosis: Clinical diagnosis of Posttraumatic Stress Disorder (PTSD) with mild to moderate-severe symptom intensity.

• Symptom Severity: A PCL-5 total score of up to 60 at screening.

• Traumatic Event: PTSD diagnosis based on a traumatic event that occurred in the year 2000 or later.

• Service Eligibility: Eligibility for Ministry of Defense (MOD) rehabilitation services.

• Technical Proficiency: Ability to use a smartphone and a wearable device.

Locations
Other Locations
Israel
NeuroBrave LTD - Remote Site
RECRUITING
Jerusalem
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 80
Treatments
Active_comparator: Mental Gym® Immediate Intervention
No_intervention: Delayed Intervention (Waitlist Control plus Garmin Watch)
Participants in this arm will initially serve as a no-intervention control group for a period of 8 weeks, during which they will continue with their Treatment as Usual (TAU). Following this 8-week period, they will receive the full 'Mental Gym®' intervention, identical to the experimental group, including the mobile application, and weekly sessions.
Related Therapeutic Areas
Sponsors
Leads: NeuroBrave ltd.

This content was sourced from clinicaltrials.gov