Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 28 days
Healthy Volunteers: f
View:

• Written informed consent by one or both parents or legal guardians

• Gestational age at birth \< 30 0/7 weeks

• Infants on sNIPPV respiratory support

• Below 4 weeks chronological age

Locations
Other Locations
Switzerland
University Hospital Zurich
RECRUITING
Zurich
Contact Information
Primary
Christoph M Rüegger, MD
christoph.rueegger@usz.ch
+41432539810
Backup
Claudia Knöpfli
claudia.knoepfli@usz.ch
+41442555340
Time Frame
Start Date: 2025-11-17
Estimated Completion Date: 2027-01-30
Participants
Target number of participants: 27
Treatments
Preterm infants with a gestational age < 30 0/7 weeks at birth
Infants on sNIPPV respiratory support and below 4 weeks chronological age
Related Therapeutic Areas
Sponsors
Leads: University of Zurich
Collaborators: University Hospital, Zürich

This content was sourced from clinicaltrials.gov