A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis

Status: Recruiting
Location: See all (44) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 130
Healthy Volunteers: f
View:

• Patient willing and able to provide written informed consent to participate in the study

• Confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis

• Aged ≥18 years at the time of signing the informed consent

• Patient willing and able to participate in collection of electronic patient reported outcomes (PROs)

Locations
United States
California
Research Site
RECRUITING
La Jolla
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Los Angeles
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San Francisco
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San Francisco
Connecticut
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New Haven
Washington, D.c.
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RECRUITING
Washington D.c.
Illinois
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NOT_YET_RECRUITING
Chicago
Indiana
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RECRUITING
Indianapolis
Massachusetts
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NOT_YET_RECRUITING
Boston
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NOT_YET_RECRUITING
Boston
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RECRUITING
Boston
Minnesota
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NOT_YET_RECRUITING
Rochester
Missouri
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RECRUITING
Kansas City
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St Louis
North Carolina
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Durham
New Jersey
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New Brunswick
New York
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Manhasset
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New York
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New York
Pennsylvania
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Philadelphia
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Philadelphia
South Carolina
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Greenville
Tennessee
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Germantown
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Nashville
Texas
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Dallas
Virginia
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Richmond
Washington
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Seattle
Wisconsin
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Milwaukee
Other Locations
Canada
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Halifax
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London
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NOT_YET_RECRUITING
Rimouski
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RECRUITING
Toronto
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RECRUITING
Vancouver
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Vancouver
Germany
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RECRUITING
Aachen
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RECRUITING
Berlin
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RECRUITING
Cologne
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Frankfurt Am Main
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RECRUITING
Hanover
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RECRUITING
Homburg
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RECRUITING
Mainz
Research Site
NOT_YET_RECRUITING
Würzburg
United Kingdom
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RECRUITING
Glasgow
Research Site
RECRUITING
London
Contact Information
Primary
AstraZeneca Clinical Study Information Center
information.center@astrazeneca.com
1-877-240-9479
Time Frame
Start Date: 2024-06-25
Estimated Completion Date: 2031-12-29
Participants
Target number of participants: 1850
Treatments
ATTR cardiomyopathy (ATTR-CM)
Patients with ATTR-CM at enrollment
Hereditary polyneuropathy (ATTRv-PN)
Patients with ATTRv-PN at enrollment
ATTR-Mixed
Patients with a mixed ATTR amyloidosis phenotype
Related Therapeutic Areas
Sponsors
Leads: AstraZeneca
Collaborators: ICON plc

This content was sourced from clinicaltrials.gov