The Impact of Systemic Light Chain Amyloidosis on Eyes and Its Appendages

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Objective: To assess the involvement of the anterior segment of the eye, as well as the extraocular soft tissues and muscles, in patients with systemic light chain amyloidosis. Secondary Objective: To assess the neuro-ophthalmic manifestations and changes in retinal choroidal blood flow in patients with systemic light chain amyloidosis. Study

Design: Observational study. Study Population and Expected Enrollment: 80 patients with systemic light chain amyloidosis, 50 normal controls. Study Duration: Six months of follow-up after the last subject is diagnosed and enrolled. Intervention: Experimental Group: Patients with systemic light chain amyloidosis; Control Group: Subjects without systemic diseases.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• Patients diagnosed with Systemic Light Chain Amyloidosis;

• No other severe systemic underlying diseases that affect the examination;

• Subjects voluntarily participate in this study, sign the informed consent form;

• Age between 18-80 years old, no gender restrictions.

• Stable general condition, not patients with Systemic Light Chain Amyloidosis;

• No other severe systemic underlying diseases that affect the examination;

• Subjects voluntarily participate in this study, sign the informed consent form;

• Age between 18-80 years old, no gender restrictions.

Locations
Other Locations
China
Zhongshan Opthalmic Center
RECRUITING
Guangzhou
Contact Information
Primary
Minglu Ma, Doctor
mingluma@126.com
86-13547891481
Backup
Yanjie Yan
iacuc@gzzoc.com
020-66610729
Time Frame
Start Date: 2024-09-04
Estimated Completion Date: 2026-08-13
Participants
Target number of participants: 130
Treatments
Exposed group
Exposed group: Ocular Complications of Systemic Light Chain Amyloidosis. Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.
Unexposed group
Unexposed group: patients without Systemic Light Chain Amyloidosis
Related Therapeutic Areas
Sponsors
Leads: Zhongshan Ophthalmic Center, Sun Yat-sen University

This content was sourced from clinicaltrials.gov