• Must have provided written informed consent

• Age 18-75 years;

• BMI 17-28 kg/m2

• Male or female with a diagnosis of PBC, by at least two of the following criteria:

‣ History of alkaline phosphatase（ALP） above upper limit of normal（ULN） for at least six months;

⁃ Positive Anti-mitochondrial antibody (AMA) titers (\>1/40 on immunofluorescence or M2 positive by enzyme linked immunosorbent assay (ELISA) or positive PBC-specific antinuclear antibodies;

⁃ Documented liver biopsy result consistent with PBC.

• Incomplete response to UDCA defined by 1 x ULN\< ALP \<= 1.67 x ULN

• Taking UDCA for at least 6 months (stable dose for ≥ 3 months) prior to Day 0