Long-term Safety and Tolerability of TAK-881 in Subjects With Primary Immunodeficiency Diseases (PIDD)

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Biological, Device
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The main aim of this study is to learn if TAK-881 is safe and well tolerated during long-term use in adults and children with PIDD who are eligible and completed study TAK-881-3001 (NCT05755035). The participants will receive the first dose of TAK-881 immunoglobulin (IgG) infusion at the same dosage as the last dose administered in study TAK-881-3001 (NCT05755035). After the first TAK-881 infusion in study TAK-881-3002, the dosing interval (can be adjusted by participant/caregiver) and/or the dose of TAK-881 can be adjusted by the study doctor to every 2, 3 or 4 weeks at scheduled site visits. Participants will visit the clinic every 12 weeks until the End of Study (EOS) visit.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Healthy Volunteers: f
View:

⁃ Participants who meet ALL of the following criteria are eligible for this study:

• Participant must have completed Study TAK-881-3001 (NCT05755035).

• Participant/Participant's parent(s)/legal guardian(s) is/are willing and able to comply with the requirements of the protocol.

• Participant/Participant's parent(s)/legal guardian(s) has/have provided informed consent/assent (if applicable), including providing consent for use of the investigational medical device, prior to the initiation of any study procedures.

Locations
United States
Georgia
Central Georgia Infectious Disease Consultants
RECRUITING
Macon
Illinois
Sneeze, Wheeze, & Itch Associates, LLC
RECRUITING
Normal
North Carolina
Duke Asthma, Allergy and Airway Center
RECRUITING
Durham
New York
Montefiore Medical Center
RECRUITING
The Bronx
Texas
Allergy Partners of North Texas
RECRUITING
Dallas
Contact Information
Primary
Takeda Contact
medinfoUS@takeda.com
+1-877-825-3327
Time Frame
Start Date: 2024-11-04
Estimated Completion Date: 2029-01-15
Participants
Target number of participants: 39
Treatments
Experimental: TAK-881
Epoch 1: Participants who completed study TAK-881-3001 (NCT05755035) and met eligibility criteria will receive TAK-881 subcutaneous (SC) infusion using investigational needle sets at the same dose and same treatment interval as at the last infusion in TAK-881-3001 (NCT05755035) at Week 1 and at Weeks 13 and Week 25 of study TAK-881-3002.~Epoch 2: Participants with anti-rHuPH20 antibody titer \>=1:160 at any time point during Study TAK-881-3001 (NCT05755035) and/or Study TAK-881-3002 Epoch 1, will continue receiving TAK-881 every 12 weeks for up to Week 121.~After the first TAK-881 infusion in study TAK-881-3002, the interval and/or the dose may be adjusted only at scheduled site visits at the investigator's discretion.
Related Therapeutic Areas
Sponsors
Collaborators: Takeda Development Center Americas, Inc., Baxalta Innovations GmbH, now part of Takeda
Leads: Takeda

This content was sourced from clinicaltrials.gov

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