Prostate Cancer Clinical Trials

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Prostate Adaptive Radiation Therapy

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Prostate ART is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for prostate cancer patients. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Part 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for prostate cancer patients.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:

• \- Age \> 18

• Biopsy proven prostate malignancy

• Definitive treatment is radiotherapy to the prostate alone

• ECOG performance status 0-2

• Ability to understand and the willingness to sign an informed consent

Locations
Other Locations
Australia
Northern Sydney Cancer Centre, Royal North Shore Hospital
RECRUITING
St Leonards
Contact Information
Primary
Nada Cheikh-Ali
nada.cheikhali@health.nsw.gov.au
+61294631345
Backup
Heidi Tsang
heidi.tsang@health.nsw.gov.au
+61294631340
Time Frame
Start Date: 2025-10-01
Estimated Completion Date: 2031-10-31
Participants
Target number of participants: 130
Treatments
Active_comparator: Adaptive radiotherapy +/- margin reduction
Phase 1 and 2: Treating Radiation Therapists (RTs) on the treatment machine will review the treatment target and organs at risk contours that are automatically generated on the plan of the day. They will modify these safely, as required, and then also approve the computer generated re-plan of the day, within the bounds of departmental protocols and decision guides (RT led).~Phase 2 only: Margin reduction facilitated by adaptive radiotherapy.
Active_comparator: Standard radiotherapy
Patients will receive standard image guided radiotherapy
Related Therapeutic Areas
Sponsors
Collaborators: Northern Sydney and Central Coast Area Health Service
Leads: Royal North Shore Hospital

This content was sourced from clinicaltrials.gov