Prostate Cancer Clinical Trials

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Navigation, Outcomes and Quality-of-life in Prostate Cancer Patients Undergoing PSMA-targeted Surgery

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

As part of a feasibility study, it's planned to use a 3D virtual mixed reality model with prostate cancer patients who show signs of lymph node metastasis and are scheduled for surgery. The model is based on PSMA PET imaging performed prior to surgery and will be evaluated by surgeons, the surgical team, and patients as part of the consultation process. First, the researcher investigates whether the removal of lymph node metastases has improved compared to the data in the literature . In addition, the study examines how the 3D model influences the movement of surgical instruments and the efficiency of surgical removal of lymph node metastases. To this end, the analyzed recorded video and position data of the instruments used during procedures performed with a surgical robot. It's also an aim to develop two methods-using landmarks and visual position tracking-for more targeted navigation during surgery. Additionally, short-term results examine, such as PSA response rates, as an indication of successful lymph node metastasis removal and patient quality of life.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 78
Healthy Volunteers: f
View:

⁃ Cohort A:

• Patients with hormone-sensitive prostate cancer scheduled for radical prostatectomy with pelvic lymph node dissection

• \<3 PSMA-PET-avid lymph node metastases (PSMA expression score \>2) in the pelvis.

⁃ Cohort B:

• Patients with hormone-sensitive recurrent prostate cancer after radical prostatectomy with planned pelvic salvage lymph node dissection

• \<3 PSMA-PET-avid lymph node metastases (PSMA expression score \>2) in the pelvis

• PSA value \<2ng/ml.

Locations
Other Locations
Germany
Anke Renter
NOT_YET_RECRUITING
Hamburg
Martini-Klinik
RECRUITING
Hamburg
Contact Information
Primary
Tobias Maurer, Professor
t.maurer@uke.de
+4940741053115
Time Frame
Start Date: 2026-01-21
Estimated Completion Date: 2028-12
Participants
Target number of participants: 102
Treatments
Experimental: preop virtual 3D model
Cohort A: Radical prostatectomy with PSMA-targeted lymph node dissection (separate specimen) and bilateral extended pelvic lymph node dissection with additional use of a virtual 3D-model (of preoperative PSMA-PET examination) prior to surgery and postoperatively; Cohort B: Salvage lymph node dissection with PSMA-targeted lymph node dissection (separate specimen) and at least ipsilateral pelvic template lymph node dissection with additional use of a virtual 3D-model (of preoperative PSMA-PET examination) prior to surgery and postoperatively
Active_comparator: Control Intervention
Cohort A: Radical prostatectomy with PSMA-targeted lymph node dissection (separate specimen) and bilateral extended pelvic lymph node dissection with use of standard PSMA-PET examination prior to surgery; only postoperatively a virtual 3D-model (of preoperative PSMA-PET examination) will be evaluated; Cohort B: Salvage lymph node dissection with PSMA-targeted lymph node dissection (separate specimen) and at least ipsilateral pelvic template lymph node dissection with use of standard PSMA-PET examination prior to surgery; only postoperatively a virtual 3D-model (of preoperative PSMA-PET examination) will be evaluated
Related Therapeutic Areas
Sponsors
Leads: Martini-Klinik am UKE GmbH

This content was sourced from clinicaltrials.gov

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