Fluorouracil-labeled Nascent RNA Technology for Evaluating the Effects of Different Hyperthermic Intraperitoneal Chemotherapy Regimens on the Transcriptome of Pseudomyxoma Peritonei
The main objective of this study is to combine HIPEC regimens with Flura-seq to detect the effects of different HIPEC regimens (cisplatin vs. cisplatin+ docetaxel) on the nascent transcriptome of PMP tumors, so as to quantitatively assess the efficacy of different HIPEC regimens in the early stage, and to lay the foundation for optimizing the HIPEC regimens and exploring new therapeutic targets.
• Age 18-75 years old, regardless of gender and race;
• Pathologically confirmed as pseudomyxoma peritonei; acceptable for CRS+HIPEC treatment;
• KPS score ≥ 60, with expected survival time more than 12 months;
• The functions of important organs are basically normal, with no significant abnormalities in liver or kidney function;
• No history of allergy to biological products;
• No serious bacterial or viral infection;
• Non-pregnancy and lactation;
• The patient or his/her delegate understands and cooperates with the treatment and signs the informed consent for the treatment.