A Multi-Site Observational Clinical Investigation to Collect Non-invasive Sensor Data During a Right Heart Catheterization and Train Machine Learning Models to Estimate Intracardiac Hemodynamic Parameters Evaluation of a Novel maChine leArning Model's Performance for Non-invasive inTracardiac pressURE Monitoring in Heart Failure - The CAPTURE-HF Trial

Status: Completed
Location: See all (18) locations...
Intervention Type: Device
Study Type: Observational
SUMMARY

Acorai is developing a non-invasive monitoring system for the estimation of intracardiac hemodynamic parameters in patients with suspected or confirmed heart failure, and/or pulmonary hypertension, who require hemodynamic assessment. The device will be intended as a companion test or clinical decision support tool to be used and interpreted by qualified healthcare professionals to aid standard-of-care clinical assessment in identifying hemodynamic congestion and supporting personalized treatment of heart failure and pulmonary congestion. This study is part of the development of a non-invasive monitoring system for the estimation of intracardiac hemodynamic parameters. It will be conducted to collect the data needed to train the machine learning models retrospectively.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
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• Subject is, at least, 18 years of age at the time of screening visit.

• Subject is willing and physically able to comply with the specified evaluations as per the clinical investigation plan, as assessed by the investigator.

• Subject is referred for invasive hemodynamic assessment with right heart cardiac catheterization.

• Patient has provided written informed consent using the Ethics Committee/ Institutional Review Board approved consent form.

Locations
United States
Arkansas
Conway Regional Cardiovascular Clinic
Conway
Baptist Health Medical Centre
Little Rock
Florida
Mayo Clinic
Jacksonville
Cleveland Clinic Martin Health
Stuart
Missouri
Saint Luke's Hospital of Kansas City
Kansas City
North Carolina
WakeMed
Raleigh
Pennsylvania
University of Pennsylvania
Philadelphia
South Carolina
Medical University of South Carolina (MUSC)
Charleston
Texas
Austin Heart Central and San Marcos
Austin
Austin Heart Round Rock
Austin
Other Locations
Belgium
Onze-Lieve-Vrouwziekenhuis (OLV) Hospital Aalst
Aalst
Canada
University of Ottawa Heart Institute
Ottawa
Mount Sinai Hospital Toronto
Toronto
Toronto General Hospital
Toronto
Denmark
Rigshospitalet, University Hospital of Copenhagen
Copenhagen
Sweden
Sahlgrenska university hospital
Gothenburg
United Kingdom
Royal Brompton and Harefield Hospitals
London
Southampton University Hospital
Southampton
Time Frame
Start Date: 2023-08-15
Completion Date: 2024-10-31
Participants
Target number of participants: 1602
Treatments
Participants phase 1
Phase 1: patients enrolled for a right heart catheterization procedure as part of their standard of care.
Participants phase 2
Phase 2: patients enrolled for a right heart catheterization procedure as part of their standard of care.
Sponsors
Leads: Acorai AB

This content was sourced from clinicaltrials.gov