Relapsed Refractory Multiple Myeloma (RRMM) Clinical Trials

• Age ≥ 18 years

• Documented diagnosis of multiple myeloma according to the IMWG diagnostic criteria

• Documented evidence of measurable disease:

‣ Serum M-protein level ≥ 1 g/dL

⁃ Urine M-protein level ≥ 200 mg/24h

⁃ Serum immunoglobulin free light chain ≥ 10 mg/dL (100 mg/L) and abnormal serum immunoglobulin kappa lambda free light chain ratio

• Documented evidence of PD by IMWG 2016 criteria based on investigator's determination during or after the most recent line of therapy. Participants with only 1 prior line of therapy must have progressed within 47 months of a stem cell transplant, or if not transplanted, then within 42 months of starting initial therapy

• Received 1 to 3 lines of prior therapy including an IMiD and either a PI or a CD38 antibody. Participant must have undergone at least 2 complete cycles of treatment for each line of therapy, unless PD was the best response to the line of therapy

• Eligible to receive at least one of the standard regimens (DKd, PVd, DPd, or Kd) as determined by the Investigator.

• ECOG performance status score of 0 to 1

• Adequate hematology and chemistry laboratory values:

‣ Haemoglobin ≥ 8.0 g/dL

⁃ Absolute neutrophil count ≥ 1 × 10\^9/L (1000 per mm3)

⁃ Platelet count ≥ 75 × 10\^9/L (75000 per mm3) in participants with \< 50% of bone marrow nucleated cells are plasma cells or ≥ 50 × 10\^9/L (50000 per mm3) in participants with ≥ 50% of bone marrow nucleated cells are plasma cells

⁃ Absolute lymphocyte count ≥ 300/µL (0.3 × 109/L)

⁃ Total bilirubin ≤ 1.5 × ULN in the absence of Gilbert's syndrome or ≤ 3 × ULN if the participant has Gilbert's syndrome. AST and ALT≤ 3.0 × ULN. CrCl by Cockcroft and Gault method ≥ 30 mL/minute