Find Renal Cell Carcinoma (RCC) Clinical Trials Near You
A Randomized, Double-Blind, Active-Control, Multicenter Phase 3 Trial of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
Status: Recruiting
Location: See all (44) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Unresectable and measurable locally advanced or metastatic renal cell carcinoma with a primary clear cell component.
• A Karnofsky Performance Status (KPS) score ≥ 80%
• At least 1 target lesion measurable by computed tomography/magnetic resonance imaging per RECIST 1.1, not within a field of prior radiation therapy.
• Adequate organ and marrow function, ≤ 72 hours prior to randomization.
• Women of childbearing potential (WOCBP) must have a negative serum pregnancy test.
Locations
United States
Arizona
City of Hope - Phoenix Cancer Center
RECRUITING
Goodyear
Mayo Clinic - Phoenix
RECRUITING
Phoenix
California
City Of Hope National Medical Center
RECRUITING
Duarte
University of California San Diego Moores Cancer Center
RECRUITING
La Jolla
UCLA Hematology Oncology - 100 Med Plaza
RECRUITING
Los Angeles
University of California San Diego Moores Cancer Center
RECRUITING
San Diego
Connecticut
Yale University
RECRUITING
New Haven
Florida
Mayo Clinic in Florida
RECRUITING
Jacksonville
Georgia
Emory University - Atlanta
RECRUITING
Atlanta
Piedmont Cancer Institute OneOncology
RECRUITING
Atlanta
City of Hope Cancer Center Atlanta
RECRUITING
Newnan
Illinois
City of Hope - Chicago Cancer Center
RECRUITING
Zion
Indiana
Indiana University Melvin and Bren Simon Cancer Center
RECRUITING
Indianapolis
Kentucky
Norton Cancer Institute PARENT
RECRUITING
Louisville
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Massachusetts General Hospital
RECRUITING
Boston
Minnesota
Mayo Clinic
RECRUITING
Rochester
Missouri
Washington University School of Medicine
RECRUITING
St Louis
North Carolina
UNC Hospitals
RECRUITING
Chapel Hill
Nebraska
The University of Nebraska Medical Center
RECRUITING
Omaha
New York
University of Rochester Medical Center
RECRUITING
Rochester
Ohio
Cleveland Clinic Foundation
RECRUITING
Cleveland
University Hospitals Cleveland Medical Center
RECRUITING
Cleveland
Oregon
Compass Oncology, OR
RECRUITING
Portland
Tennessee
SCRI Oncology Partners
RECRUITING
Nashville
Vanderbilt
RECRUITING
Nashville
Texas
Texas Tech University Health Science Center
RECRUITING
Lubbock
Utah
The University of Utah - Huntsman Cancer Institute (HCI)
RECRUITING
Salt Lake City
Other Locations
France
CHU Brest - Hôpital Morvan
RECRUITING
Brest
Hopital Saint Eloi
RECRUITING
Montpellier
Institut Gustave Roussy
RECRUITING
Villejuif
Germany
Krankenhaus Nordwest GmbH
RECRUITING
Frankfurt
Universitaetsklinikum Halle (Saale)
RECRUITING
Halle
Universitaetsmedizin Rostock
RECRUITING
Rostock
Netherlands
Radboudumc
RECRUITING
Nijmegen
Isala
RECRUITING
Zwolle
Poland
Pratia MCM Krakow
RECRUITING
Krakow
Republic of Korea
CHA Bundang Medical Center, CHA University
RECRUITING
Seongnam
Severance Hospital, Yonsei University Health System