Assessment of Quality of Life and Outcomes in Patients Treated With Stereotactic Body Radiotherapy (SBRT) for Inoperable Renal Cell Carcinoma (RCC): A Multicenter Phase II Study
Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a multicenter, single arm phase II study of stereotactic body radiation therapy (SBRT) for patients with medically inoperable primary renal cell carcinoma (RCC).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients ≥18 years old
• Newly diagnosed RCC by biopsy (preferred) or radiologic evidence of growth on surveillance over two consecutive assessments (6-12 months)
• Primary lesion \>3 cm, or recurrent lesion following local ablative therapy
• Medically inoperable or patient who refuses surgery following assessment by experienced urologist, and discussed in a multidisciplinary setting
• ECOG 0-2
• Written informed consent
• Participants must be able to understand the English-language or with the aid of a translator
Locations
Other Locations
Canada
Sunnybrook Health Sciences
RECRUITING
Toronto
Contact Information
Primary
Chris Zehr
chris.zehr@sunnybrook.ca
416-480-6100
Backup
Kerri Durrant
keri.durrant@sunnybrook.ca
416-480-6100
Time Frame
Start Date: 2022-02-08
Estimated Completion Date: 2026-10-01
Participants
Target number of participants: 70
Treatments
Experimental: SBRT for Medically Inoperable RCC
35-45 Gy in five fractions (7-9 Gy/day)
Related Therapeutic Areas
Sponsors
Leads: Sunnybrook Health Sciences Centre
Collaborators: British Columbia Cancer Agency, Juravinski Cancer Center, Health Sciences North, Grand River Regional Cancer Centre, Durham Regional Cancer Centre, London Health Sciences Centre