Response to the Combination of Stereotactic Body Radiation Therapy and Concurrent PD-1 Blockade in Patients With Metastatic Renal Cell Carcinoma: a Retrospective Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Prior research has indicated that stereotactic body radiotherapy (SBRT) can effectively trigger systemic anti-tumor immune response. The goal of this observational study is to learn about abscopal effects of stereotactic body radiotherapy and concurrent anti-PD-1 antibody treatment in patients of metastatic clear renal cell carcinoma. The primary objective was to assess the objective response rate (ORR) in non-irradiated lesions, and incidence of adverse events (AEs).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age≥18 years at the time of signing informed consent;

• Histologically confirmed, advanced renal cell carcinoma of stage IV (AJCC 8);

• Previously received SBRT and concurrent PD-1 blockade treatment;

• Evidence of measurable metastatic kidney cancer according to RECIST 1.1 criteria.

Locations
Other Locations
China
Nanfang Hospital, Southern Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Guozhu Xie
xieguozhu@126.com
02062787693
Time Frame
Start Date: 2023-10-01
Estimated Completion Date: 2025-06-30
Participants
Target number of participants: 20
Related Therapeutic Areas
Sponsors
Leads: Nanfang Hospital, Southern Medical University

This content was sourced from clinicaltrials.gov