Comparison of [18F] PSMA-1007 PET/CT and Conventional Imaging in the Detection of Metastatic Clear Cell Renal Cell Carcinoma

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

Staging of kidney cancer is primarily achieved by computerized tomography (CT) scans or magnetic resonance imaging (MRI). If a patient is found to have limited metastatic disease, surgical removal or radiation therapy could be considered in order to control the majority of the disease. However, if metastases are more widespread, systemic (drug) therapy may be the preferred management option. The identification of additional metastatic sites using more sensitive imaging modalities therefore has the potential to alter management, and this remains an unmet need in the field. This study will investigate the utility of positron emission tomography (PET) imaging with PSMA (prostate specific membrane antigen). Kidney cancer of the clear cell subtype has demonstrated high expression of PSMA, making it a disease in which PSMA-targeted PET imaging could help to identify occult metastatic disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Men and women with histologically-proven, metastatic renal cell carcinoma (RCC)(TNM stage Tany, Nany, M1)

• Must have baseline conventional imaging of the chest, abdomen, and pelvis with contrast-enhanced CT or MRI within 5 weeks of enrolment. Contrast is required unless the participant cannot for medical reasons (ie renal failure).

⁃ Exception: Unenhanced CT of the chest is acceptable Exception: Unenhanced MRI of abdomen and pelvis is acceptable in cases of renal failure

Locations
Other Locations
Canada
London Health Sciences Centre - Victoria Hospital
RECRUITING
London
Contact Information
Primary
Kaydee Connors
kaydee.connors@lhsc.on.ca
519-685-8500
Backup
Nicole Phillips
nicole.phillips@lhsc.on.ca
519-685-8500
Time Frame
Start Date: 2022-01-24
Estimated Completion Date: 2025-09
Participants
Target number of participants: 30
Treatments
Experimental: [18F] PSMA-1007 PET/CT
All patients enrolled undergo a \[18F\] PSMA-1007 PET/CT
Related Therapeutic Areas
Sponsors
Leads: Western University

This content was sourced from clinicaltrials.gov