An Observational Study of the Efficacy and Safety of Vorolanib in the Second-line Treatment of Patients With Unresectable or Metastatic Renal Cell Carcinoma

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

This is a multicenter real world study (RWS) initiated by the investigator. Eligible patients will be selected for treatment with second-line treatment including vorolanib and followed up. The real survival data of patients after medication will be collected and compared with the data of CONCEPT study, and multi-factor stratified analysis of the efficacy of voronib will be conducted.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Subjects have fully understood and voluntarily signed the informed consent form (ICF);

• 18-80 years old (at the time of signing the informed consent); Both men and women; ECOG PS score: 0-1;

• Renal cell carcinoma with clear cell components confirmed histologically or cytopathologically, including unresectable or recurrent metastatic renal cell carcinoma dominated by clear cell components;

• According to RECIST (version 1.1), there are targets that are considered to be observable;

• The main organs function well.

Locations
Other Locations
China
Jinling Hospital
RECRUITING
Nanjing
Contact Information
Primary
Le Qu, M. D.
septsoul@hotmail.com
+86 15720625951
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2026-09-01
Participants
Target number of participants: 39
Treatments
Experimental cohort.
Subjects who progressed after first-line treatment and switched to second-line treatment regimens including vorolanib. The first-line treatment which patients received can be other tyrosine kinase inhibitors (TKIs) or TKIs combined with immunotherapy drugs. Provided vorolanib is contained in the second-line regimen, the patient then can be considered for inclusion in the study.
Related Therapeutic Areas
Sponsors
Leads: Jinling Hospital, China

This content was sourced from clinicaltrials.gov