Evaluation of Muscle Involvement in Systemic Sclerosis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Muscle involvement is poorly described in patients with systemic sclerosis (SSc) . The prevalence of muscle damage is evaluated at 5-95 % of SSc patients, particularly due to variable definitions depending on the series in the scientific litterature. Muscle clinicobiological and histological presentation an response to immunosuppressive treatments are highly variable. Muscle involvement defined by creatinine kinase (CK) elevation, the presence of electromyography (EMG) abnormalities and/or muscle magnetic resonance imaging (MRI) hyperintensities and/or muscle biopsy inflammation appears to be associated with diffuse SSc, the presence of cardiac damage, and anti-PM-Scl antibodies. The main objective is to describe muscular manifestations associated with SSc. Secondary objectives are: * to compare characteristics between SSc patients with and without muscle involvement * to determine homogeneous groups of SSc patients with muscle involvement

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with systemic sclerosis according to 2013 ACR/EULAR classification criteria

Locations
Other Locations
France
Paul Decker
RECRUITING
Nancy
Contact Information
Primary
Paul Decker, MD
p.decker@chru-nancy.fr
+33383157240
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 150
Treatments
SSc patients
Related Therapeutic Areas
Sponsors
Leads: Central Hospital, Nancy, France

This content was sourced from clinicaltrials.gov