Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) Study
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation. An important cause of impaired hand function are contractures of the hand, which are reported in up to a half of patients. With this longitudinal cohort study in patients with SSc and VEDOSS (very early diagnosis of systemic sclerosis) the investigators aim to gain more insight into processes involved in hand function impairment.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age \> 18 years
Locations
Other Locations
Netherlands
UMC Utrecht
RECRUITING
Utrecht
Time Frame
Start Date: 2024-04-19
Estimated Completion Date: 2028-04
Participants
Target number of participants: 300
Treatments
VEDOSS
defined as RP, presence of SSc specific autoantibodies (ACA, ATA, ARA), puffy fingers and abnormal nailfold capillaroscopy (giant capillaries or capillary loss with or without haemorrhages), but not fulfilling the EULAR-ACR 2013 classification criteria for SSc
SSc with disease duration of < 4 years without hand contractures
SSc with hand contractures
Related Therapeutic Areas
Sponsors
Collaborators: University Medical Center Groningen, Royal Free Hospital NHS Foundation Trust, Radboud University Medical Center, Leiden University Medical Center
Leads: UMC Utrecht