Long-term Effect of General Anesthesia Before School Age on Neurodevelopment in Children With Congenital Scoliosis

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

In the past, a large number of animal studies have suggested that anesthesia exposure has potential neurotoxic effects, resulting in persistent cognitive and behavioral deficits. At present, there is still a lack of sufficient clinical research evidence to prove whether anesthesia exposure has long-term effects on neurodevelopment. The existing clinical research data suggests that a single short-time anesthesia exposure in young children does not affect long-term neurodevelopmental outcomes. Early onset scoliosis, including congenital scoliosis, is a type of scoliosis deformity that occurs before the age of 10. Posterior scoliosis correction surgery is one of the common treatment. There is currently no research indicating the impact of early single or multiple long-duration anesthesia exposure on the neurological development of children with congenital scoliosis. The aim of this study is to determine the long-term effect of general anesthesia exposure on neurocognitive function and behavior in children with congenital scoliosis, in order to provide reference for related clinical work.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 16
Healthy Volunteers: f
View:

• Diagnosed with congenital scoliosis

• 6-16 years old at the time of assessment

Locations
Other Locations
China
Peking Union Medical College Hospital
RECRUITING
Beijing
Contact Information
Primary
Lulu Ma, Dr.
malulu@pumch.cn
0086-10-13811049619
Backup
Ziyi Dai, Dr.
daiziyi@pumch.cn
0086-10-18611703606
Time Frame
Start Date: 2020-07-13
Estimated Completion Date: 2026-12
Participants
Target number of participants: 150
Treatments
Unexposed
Children unexposed to general anesthesia before school age (\<=6y)
Singly exposed
Children singly exposed to general anesthesia before school age (\<=6y)
Multiply exposed
Children multiply exposed to general anesthesia before school age (\<=6y)
Related Therapeutic Areas
Sponsors
Leads: Peking Union Medical College Hospital

This content was sourced from clinicaltrials.gov