Haemdall: Developing a Quantitative MRI Biomarker of Classical (Infratentorial) Superficial Siderosis of the Central Nervous System
Haemdall: Using Medical Imaging to measure Brain Iron in Superficial Siderosis. This study is looking at a new way of using MRI scans to potentially measure the amount of iron on the surface of the brain. Iron build up in the brain is linked to how superficial siderosis develops. The study will also aim to see if there is a connection between the amount of iron in the brain and common superficial siderosis symptoms. Clinical tests will be used to measure symptoms including tests to measure your hearing, walking \& balance and participants' ability to remember, think and understand.
⁃ Superficial siderosis cohort:
• Male or female adults of 18 years of age or older with a confirmed diagnosis of superficial siderosis
• Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
• Participants willing and able to give informed consent for participation in the investigation
⁃ Healthy cohort:
• Male or female over 18 years of age without a diagnosis of a neurological disorder
• Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
• Participants willing and able to give informed consent for participation in the investigation