• Adult participants must be 18 years of age or older

• Advanced or metastatic solid tumors excluding primary central nervous system (CNS) tumors

• For Module 1 only, Have documented evidence of BRCA1/2 and/or genetic alterations conferring homologous recombination deficiency (HRD) (ATM, BARD1, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, PPP2R2A, RAD51B, RAD51C, RAD51D, RAD54L, NBN, FANCA)

• For Module 2 only, results of MSI and/or MMR testing required.

• For Module 2 only, results of BRCA1/2 and HRD gene testing required.

• Participant must have progressed on at least one prior line of therapy in the advanced or metastatic setting that is considered an appropriate standard of care, or for which the participant has documented intolerance

• For Module 2 only, advanced or metastatic Endometrial Cancer (uterine carcinosarcoma is excluded)

• For Module 2 only, Must have progressed on treatment with an anti-PD-1/L1 monoclonal antibody (MAB)