A Randomized, Double Blind, Multicenter Phase 3 Trial of BMS-986489 (BMS-986012+Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide vs Atezolizumab in Combination With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Status: Recruiting
Location: See all (187) locations...
Intervention Type: Biological, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC).
• Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale.
• Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system
Locations
United States
Alabama
Southern Cancer Center, PC
RECRUITING
Daphne
Arkansas
Local Institution - 0283
COMPLETED
Hot Springs
Florida
Florida Cancer Specialists - South
RECRUITING
Fort Myers
Mid Florida Hematology and Oncology Center
RECRUITING
Orange City
Florida Cancer Specialists - North
RECRUITING
St. Petersburg
Georgia
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING
Marietta
Illinois
Illinois Cancer Care
RECRUITING
Peoria
Minnesota
Local Institution - 0037
WITHDRAWN
Minneapolis
North Carolina
Duke Cancer Institute
RECRUITING
Durham
New Mexico
University of New Mexico Comprehensive Cancer Center
RECRUITING
Albuquerque
Ohio
Oncology Hematology Care
RECRUITING
Cincinnati
Local Institution - 0239
NOT_YET_RECRUITING
Cleveland
South Dakota
Sanford Cancer Center
RECRUITING
Sioux Falls
Tennessee
Local Institution - 0307
NOT_YET_RECRUITING
Knoxville
SCRI Oncology Partners
RECRUITING
Nashville
Texas
Texas Oncology - Central/South Texas
RECRUITING
Austin
Texas Oncology - Northeast Texas
RECRUITING
Tyler
Virginia
Oncology & Hematology Associates of Southwest Virginia, Inc.
RECRUITING
Roanoke
Washington
Swedish Cancer Institute - Edmonds
RECRUITING
Edmonds
Swedish Medical Center
RECRUITING
Seattle
Local Institution - 0007
NOT_YET_RECRUITING
Tacoma
Other Locations
Argentina
Hospital Italiano de Buenos Aires
RECRUITING
Abb
Local Institution - 0100
WITHDRAWN
Buenos Aires
Clinica Adventista Belgrano
RECRUITING
Caba
Instituto Alexander Fleming
RECRUITING
Ciudad Autónoma De Buenos Aires
Instituto Médico Río Cuarto
RECRUITING
Río Cuarto
Australia
Grampians Health
RECRUITING
Ballarat Central
Gallipoli Medical Research Ltd
RECRUITING
Brisbane
GenesisCare - Campbelltown
RECRUITING
Campbelltown
St. John of God Murdoch Hospital
RECRUITING
Murdoch
Nepean Hospital
RECRUITING
Penrith
Austria
Medizinische Universität Graz
RECRUITING
Graz
Kepler Universitätsklinikum
RECRUITING
Linz
Landeskrankenhaus Rankweil
RECRUITING
Rankweil
Local Institution - 0250
NOT_YET_RECRUITING
Vienna
Klinikum Wels-Grieskirchen GmbH
RECRUITING
Wels
Belgium
Cliniques universitaires Saint-Luc
RECRUITING
Brussels
UZ Gent
RECRUITING
Ghent
Local Institution - 0180
NOT_YET_RECRUITING
Leuven
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
RECRUITING
Liège
VITAZ
RECRUITING
Sint-niklaas
Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
RECRUITING
Barretos
Hospital São Carlos
RECRUITING
Fortaleza
Clínica de Neoplasias Litoral
RECRUITING
Itajaí
Hospital de Clinicas de Porto Alegre
RECRUITING
Porto Alegre
Hospital São Lucas da PUCRS
RECRUITING
Porto Alegre
Instituto de Oncologia Saint Gallen
RECRUITING
Santa Cruz Do Sul
A. C. Camargo Cancer Center
RECRUITING
São Paulo
Canada
CIUSSS- saguenay-Lac-Saint-Jean
RECRUITING
Chicoutimi
Cross Cancer Institute
RECRUITING
Edmonton
IUCPQ
RECRUITING
Québec
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski
RECRUITING
Rimouski
Chile
Bradfordhill
RECRUITING
Santiago
Fundacion Arturo Lopez Perez (FALP)
RECRUITING
Santiago
Orlandi Oncologia
RECRUITING
Santiago
Pontificia Universidad Catolica de Chile
RECRUITING
Santiago
Oncocentro Apys
RECRUITING
Viña Del Mar
China
Beijing Cancer hospital
RECRUITING
Beijing
Beijing Chest Hospital,Capital Medical University
RECRUITING
Beijing
Jilin Province Tumor Hospital
RECRUITING
Changchun
Local Institution - 0216
NOT_YET_RECRUITING
Changsha
Sichuan Cancer hospital
RECRUITING
Chengdu
Chongqing University Cancer Hospital
RECRUITING
Chongqing
Fujian Cancer Hospital
RECRUITING
Fuzhou
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING
Hangzhou
Zhejiang Cancer Hospital
RECRUITING
Hangzhou
Local Institution - 0227
NOT_YET_RECRUITING
Harbin
Shandong Cancer Hospital
RECRUITING
Jinan
Taizhou Hospital of Zhejiang Province
RECRUITING
Linhai
The First Affiliated Hospital of Nanchang University
RECRUITING
Nanchang
Shanghai Chest Hospital
RECRUITING
Shanghai
Shanghai East Hospital
RECRUITING
Shanghai
Zhongshan Hospital,Fudan University
RECRUITING
Shanghai
Cancer Hospital of Shantou University Medical College
RECRUITING
Shantou
Local Institution - 0235
NOT_YET_RECRUITING
Shenyang
Tianjin Medical University Cancer Institute & Hospital
RECRUITING
Tianjin
Hubei Cancer Hospital
RECRUITING
Wuhan
Tongji Hospital Tongji Medical,Science & Technology
RECRUITING
Wuhan
Xi'an International Medical Center Hospital
RECRUITING
Xi'an
The First Affiliated hospital of Xiamen University
RECRUITING
Xiamen
France
Centre Hospitalier Intercommunal de Créteil
RECRUITING
Créteil
L Hopital Nord Ouest
RECRUITING
Gleizé
Chu Grenoble Alpes
RECRUITING
La Tronche
CHU Lille - Institut Coeur Poumon
RECRUITING
Lille
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
RECRUITING
Marseille
Hôpital Arnaud de Villeneuve - CHU Montpellier
RECRUITING
Montpellier
Institut Curie
RECRUITING
Paris
Centre Hospitalier Lyon Sud
RECRUITING
Pierre-bénite
Centre Hospitalier de Cornouaille Quimper - Concarneau
RECRUITING
Quimper
Gustave Roussy
RECRUITING
Villejuif
Germany
Zentralklinik Bad Berka
RECRUITING
Bad Berka
Local Institution - 0263
NOT_YET_RECRUITING
Berlin
Klinikum Köln-Merheim
RECRUITING
Cologne
Krankenhaus Nordwest GmbH
RECRUITING
Frankfurt Am Main
Asklepios Klinik Gauting GmbH
RECRUITING
Gauting
LungenClinic Grosshansdorf
RECRUITING
Großhansdorf
Krankenhaus Martha-Maria Halle-Dölau
RECRUITING
Halle
Thoraxklinik-Heidelberg gGmbH
RECRUITING
Heidelberg
Pius Hospital Oldenburg
RECRUITING
Oldenburg
Robert Bosch Krankenhaus GmbH
RECRUITING
Stuttgart
Greece
Errikos Dunant Hospital Center
RECRUITING
Athens
Thoracic General Hospital of Athens I Sotiria
RECRUITING
Athens
University General Hospital of Larissa
RECRUITING
Larissa
European Interbalkan Medical Center
RECRUITING
Thessaloniki
Theagenio Cancer Hospital of Thessaloniki
RECRUITING
Thessaloniki
India
Local Institution - 0274
NOT_YET_RECRUITING
Bengaluru
Local Institution - 0273
NOT_YET_RECRUITING
Kolkata
Local Institution - 0271
NOT_YET_RECRUITING
Madurai
Local Institution - 0278
NOT_YET_RECRUITING
New Delhi
Local Institution - 0277
NOT_YET_RECRUITING
Varanasi
Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING
Bologna
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING
Milan
Istituto Europeo di Oncologia IRCCS
RECRUITING
Milan
Istituto Nazionale Tumori IRCCS Fondazione Pascale
RECRUITING
Napoli
AO Santa Maria della Misericordia
RECRUITING
Perugia
Casa di Cura Dott. Pederzoli
RECRUITING
Peschiera Del Garda
Istituto Nazionale Tumori Regina Elena
RECRUITING
Rome
Japan
Nippon Medical School Hospital
RECRUITING
Bunkyo-ku
Fukushima Medical University
RECRUITING
Fukushima
Hamamatsu University Hospital
RECRUITING
Hamamatsu
Saitama Medical University International Medical Center
RECRUITING
Hidaka
Kansai Medical University Hospital
RECRUITING
Hirakata
Saitama Prefectural Cancer Center
RECRUITING
Ina-machi
Kanazawa University Hospital
RECRUITING
Kanazawa
Nara Medical University Hospital
RECRUITING
Kashihara
Kobe City Medical Center General Hospital
RECRUITING
Kobe
The Cancer Institute Hospital of JFCR
RECRUITING
Koto
Kurashiki Central Hospital
RECRUITING
Kurashiki
Kurume University Hospital
RECRUITING
Kurume
National Hospital Organization Shikoku Cancer Center
RECRUITING
Matsuyama
Kindai University Hospital- Osakasayama Campus
RECRUITING
Ōsaka-sayama
Hokkaido University Hospital
RECRUITING
Sapporo
Sendai Kousei Hospital
RECRUITING
Sendai
Osaka Medical and Pharmaceutical University Hospital
RECRUITING
Takatsuki
Kanagawa Cardiovascular and Respiratory Center
RECRUITING
Yokohama
Malaysia
Hospital Kuala Lumpur
RECRUITING
Kuala Lumpur
Local Institution - 0312
NOT_YET_RECRUITING
Kuala Lumpur
Sarawak General Hospital
RECRUITING
Kuching
Mexico
Local Institution - 0146
NOT_YET_RECRUITING
Guadalajara
Local Institution - 0147
NOT_YET_RECRUITING
Monterrey
Local Institution - 0148
NOT_YET_RECRUITING
Pachuca
Local Institution - 0145
NOT_YET_RECRUITING
Puebla City
Netherlands
Amsterdam UMC, locatie VUmc
RECRUITING
Amsterdam
Ziekenhuis Rijnstate
RECRUITING
Arnhem
University Medical Center Groningen
RECRUITING
Groningen
Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka
RECRUITING
Bydgoszcz
Przychodnia Lekarska KOMED
RECRUITING
Konin
Instytut Centrum Zdrowia Matki Polki
RECRUITING
Lodz
Pratia Poznań
RECRUITING
Poznan
Szpital Specjalistyczny w Prabutach Spolka z o.o.
RECRUITING
Prabuty
Republic of Korea
Chungbuk National University Hospital
RECRUITING
Cheongju-si
Keimyung University Dongsan Hospital
RECRUITING
Daegu
Seoul National University Bundang Hospital
RECRUITING
Seongnam
Asan Medical Center
RECRUITING
Seoul
Severance Hospital, Yonsei University Health System
RECRUITING
Seoul
Ajou University Hospital
RECRUITING
Suwon
Romania
Institutul Oncologic Bucuresti
RECRUITING
Bucharest
SC Memorial Healthcare International SRL
RECRUITING
Bucharest
Institutul Oncologic Cluj
RECRUITING
Cluj-napoca
Centrul de Oncologie Sfântul Nectarie
RECRUITING
Craiova
SC Radiotherapy Center Cluj SRL
RECRUITING
Florești
Institutul Regional de Oncologie
RECRUITING
Iași
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING
Iași
Spain
Hospital Clínic de Barcelona
RECRUITING
Barcelona
Hospital de la Santa Creu i Sant Pau
RECRUITING
Barcelona
Hospital Universitario de Jaen
RECRUITING
Jaén
Hospital Universitario 12 de Octubre
RECRUITING
Madrid
Hospital Universitario Ramón y Cajal
RECRUITING
Madrid
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING
Majadahonda
CHUS - Hospital Clinico Universitario
RECRUITING
Santiago De Compostela
Hospital Universitario Virgen Del Rocio
RECRUITING
Seville
Local Institution - 0299
NOT_YET_RECRUITING
Seville
Hospital General Universitario de Valencia
RECRUITING
Valencia
Switzerland
Kantonsspital Graubünden
RECRUITING
Chur
Kantonsspital Winterthur
RECRUITING
Winterthur
UniversitätsSpital Zürich
RECRUITING
Zurich
Turkey
Local Institution - 0154
NOT_YET_RECRUITING
Adana
Local Institution - 0157
NOT_YET_RECRUITING
Ankara
Local Institution - 0177
NOT_YET_RECRUITING
Ankara
Local Institution - 0158
NOT_YET_RECRUITING
Çiğli
Local Institution - 0153
NOT_YET_RECRUITING
Istanbul
United Kingdom
Aberdeen Royal Infirmary
RECRUITING
Aberdeen
James Cook University Hospital
RECRUITING
Central Middlesbrough
Local Institution - 0108
NOT_YET_RECRUITING
Leicester
Local Institution - 0197
NOT_YET_RECRUITING
London
The Christie NHS Foundation Trust
RECRUITING
Manchester
The Clatterbridge Cancer Centre
RECRUITING
Metropolitan Borough Of Wirral
Contact Information
Primary
BMS Clinical Trials Contact Center www.BMSClinicaltrials.com
Clinical.Trials@BMS.com
855-907-3286
Backup
First line of the email MUST contain the NCT# and Site#
Time Frame
Start Date: 2025-02-25
Estimated Completion Date: 2031-09-05
Participants
Target number of participants: 530
Treatments
Experimental: Arm A
Active_comparator: Arm B
Related Therapeutic Areas
Sponsors
Leads: Bristol-Myers Squibb