A Randomized, Double Blind, Multicenter Phase 3 Trial of BMS-986489 (BMS-986012+Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide vs Atezolizumab in Combination With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Status: Recruiting
Location: See all (179) locations...
Intervention Type: Biological, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC).
• Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale.
• Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system
Locations
United States
Alabama
Southern Cancer Center, PC
RECRUITING
Daphne
Arkansas
Local Institution - 0283
COMPLETED
Hot Springs
Florida
Florida Cancer Specialists - South
RECRUITING
Fort Myers
Mid Florida Hematology and Oncology Center
RECRUITING
Orange City
Florida Cancer Specialists - North
RECRUITING
St. Petersburg
Georgia
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING
Marietta
Illinois
Illinois Cancer Care
RECRUITING
Peoria
Minnesota
Local Institution - 0037
WITHDRAWN
Minneapolis
North Carolina
Duke Cancer Institute
RECRUITING
Durham
North Dakota
Sanford Medical Center
RECRUITING
Bismarck
Sanford Fargo Medical Center
RECRUITING
Fargo
New Mexico
University of New Mexico Comprehensive Cancer Center
RECRUITING
Albuquerque
Ohio
Oncology Hematology Care
RECRUITING
Cincinnati
South Dakota
Sanford Cancer Center
RECRUITING
Sioux Falls
Tennessee
SCRI Oncology Partners
RECRUITING
Nashville
Texas
Texas Oncology - Central/South Texas
RECRUITING
Austin
Texas Oncology - Northeast Texas
RECRUITING
Tyler
Virginia
Oncology & Hematology Associates of Southwest Virginia, Inc.
RECRUITING
Roanoke
Washington
Swedish Cancer Institute - Edmonds
RECRUITING
Edmonds
Swedish Medical Center
RECRUITING
Seattle
Other Locations
Argentina
Local Institution - 0077
ACTIVE_NOT_RECRUITING
Abb
Local Institution - 0100
WITHDRAWN
Buenos Aires
Local Institution - 0080
ACTIVE_NOT_RECRUITING
Caba
Local Institution - 0079
COMPLETED
Ciudad Autónoma De Buenos Aires
Local Institution - 0094
ACTIVE_NOT_RECRUITING
Río Cuarto
Australia
Local Institution - 0190
ACTIVE_NOT_RECRUITING
Ballarat Central
Local Institution - 0105
ACTIVE_NOT_RECRUITING
Brisbane
Local Institution - 0202
ACTIVE_NOT_RECRUITING
Campbelltown
Local Institution - 0175
ACTIVE_NOT_RECRUITING
Murdoch
Local Institution - 0106
ACTIVE_NOT_RECRUITING
Penrith
Austria
Local Institution - 0253
ACTIVE_NOT_RECRUITING
Graz
Local Institution - 0252
ACTIVE_NOT_RECRUITING
Linz
Local Institution - 0255
ACTIVE_NOT_RECRUITING
Rankweil
Local Institution - 0251
ACTIVE_NOT_RECRUITING
Wels
Belgium
Local Institution - 0198
ACTIVE_NOT_RECRUITING
Brussels
Local Institution - 0091
ACTIVE_NOT_RECRUITING
Ghent
Local Institution - 0092
ACTIVE_NOT_RECRUITING
Liège
Local Institution - 0187
ACTIVE_NOT_RECRUITING
Sint-niklaas
Brazil
Local Institution - 0178
ACTIVE_NOT_RECRUITING
Barretos
Local Institution - 0166
ACTIVE_NOT_RECRUITING
Fortaleza
Local Institution - 0163
ACTIVE_NOT_RECRUITING
Itajaí
Local Institution - 0165
ACTIVE_NOT_RECRUITING
Porto Alegre
Local Institution - 0169
ACTIVE_NOT_RECRUITING
Porto Alegre
Local Institution - 0170
COMPLETED
Santa Cruz Do Sul
Local Institution - 0111
ACTIVE_NOT_RECRUITING
São Paulo
Canada
Local Institution - 0290
ACTIVE_NOT_RECRUITING
Chicoutimi
Local Institution - 0289
ACTIVE_NOT_RECRUITING
Edmonton
Local Institution - 0288
ACTIVE_NOT_RECRUITING
Québec
Local Institution - 0287
ACTIVE_NOT_RECRUITING
Rimouski
Chile
Local Institution - 0083
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0084
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0085
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0086
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0082
ACTIVE_NOT_RECRUITING
Viña Del Mar
China
Local Institution - 0204
COMPLETED
Beijing
Local Institution - 0336
ACTIVE_NOT_RECRUITING
Beijing
Local Institution - 0244
ACTIVE_NOT_RECRUITING
Changchun
Local Institution - 0216
ACTIVE_NOT_RECRUITING
Changsha
Local Institution - 0330
ACTIVE_NOT_RECRUITING
Chengdu
Local Institution - 0203
ACTIVE_NOT_RECRUITING
Chongqing
Local Institution - 0308
ACTIVE_NOT_RECRUITING
Fuzhou
Local Institution - 0236
ACTIVE_NOT_RECRUITING
Hangzhou
Local Institution - 0237
ACTIVE_NOT_RECRUITING
Hangzhou
Local Institution - 0227
ACTIVE_NOT_RECRUITING
Harbin
Local Institution - 0200
ACTIVE_NOT_RECRUITING
Jinan
Local Institution - 0229
ACTIVE_NOT_RECRUITING
Linhai
Local Institution - 0233
ACTIVE_NOT_RECRUITING
Nanchang
Local Institution - 0186
ACTIVE_NOT_RECRUITING
Shanghai
Local Institution - 0206
ACTIVE_NOT_RECRUITING
Shanghai
Local Institution - 0210
ACTIVE_NOT_RECRUITING
Shanghai
Local Institution - 0234
ACTIVE_NOT_RECRUITING
Shantou
Local Institution - 0235
NOT_YET_RECRUITING
Shenyang
Local Institution - 0213
ACTIVE_NOT_RECRUITING
Tianjin
Local Institution - 0208
ACTIVE_NOT_RECRUITING
Wuhan
Local Institution - 0209
ACTIVE_NOT_RECRUITING
Wuhan
Local Institution - 0335
COMPLETED
Xi'an
Local Institution - 0212
COMPLETED
Xiamen
France
Local Institution - 0047
COMPLETED
Créteil
Local Institution - 0044
COMPLETED
Gleizé
Local Institution - 0040
ACTIVE_NOT_RECRUITING
La Tronche
Local Institution - 0052
COMPLETED
Lille
Local Institution - 0043
ACTIVE_NOT_RECRUITING
Marseille
Local Institution - 0048
COMPLETED
Montpellier
Local Institution - 0050
ACTIVE_NOT_RECRUITING
Paris
Local Institution - 0051
ACTIVE_NOT_RECRUITING
Pierre-bénite
Local Institution - 0215
ACTIVE_NOT_RECRUITING
Quimper
Local Institution - 0038
ACTIVE_NOT_RECRUITING
Villejuif
Germany
Local Institution - 0257
ACTIVE_NOT_RECRUITING
Bad Berka
Local Institution - 0261
ACTIVE_NOT_RECRUITING
Cologne
Local Institution - 0256
ACTIVE_NOT_RECRUITING
Frankfurt Am Main
Local Institution - 0258
ACTIVE_NOT_RECRUITING
Gauting
Local Institution - 0259
ACTIVE_NOT_RECRUITING
Großhansdorf
Local Institution - 0265
ACTIVE_NOT_RECRUITING
Halle
Thoraxklinik-Heidelberg gGmbH
RECRUITING
Heidelberg
Local Institution - 0262
ACTIVE_NOT_RECRUITING
Oldenburg
Local Institution - 0264
ACTIVE_NOT_RECRUITING
Stuttgart
Greece
Local Institution - 0063
ACTIVE_NOT_RECRUITING
Athens
Local Institution - 0064
ACTIVE_NOT_RECRUITING
Athens
Local Institution - 0059
COMPLETED
Larissa
Local Institution - 0058
ACTIVE_NOT_RECRUITING
Thessaloniki
Local Institution - 0062
COMPLETED
Thessaloniki
India
Local Institution - 0274
ACTIVE_NOT_RECRUITING
Bengaluru
Local Institution - 0273
ACTIVE_NOT_RECRUITING
Kolkata
Local Institution - 0271
ACTIVE_NOT_RECRUITING
Madurai
Local Institution - 0278
WITHDRAWN
New Delhi
Local Institution - 0277
ACTIVE_NOT_RECRUITING
Varanasi
Italy
Local Institution - 0074
ACTIVE_NOT_RECRUITING
Bologna
Local Institution - 0067
ACTIVE_NOT_RECRUITING
Milan
Local Institution - 0068
ACTIVE_NOT_RECRUITING
Milan
Local Institution - 0072
ACTIVE_NOT_RECRUITING
Naples
Local Institution - 0110
ACTIVE_NOT_RECRUITING
Perugia
Local Institution - 0070
ACTIVE_NOT_RECRUITING
Peschiera Del Garda
Local Institution - 0069
ACTIVE_NOT_RECRUITING
Rome
Japan
Local Institution - 0326
ACTIVE_NOT_RECRUITING
Bunkyo-ku
Local Institution - 0327
ACTIVE_NOT_RECRUITING
Fukushima
Local Institution - 0322
ACTIVE_NOT_RECRUITING
Hamamatsu
Local Institution - 0320
ACTIVE_NOT_RECRUITING
Hidaka
Local Institution - 0317
ACTIVE_NOT_RECRUITING
Hirakata
Local Institution - 0318
ACTIVE_NOT_RECRUITING
Ina-machi
Local Institution - 0321
ACTIVE_NOT_RECRUITING
Kanazawa
Local Institution - 0324
COMPLETED
Kashihara
Local Institution - 0323
ACTIVE_NOT_RECRUITING
Kobe
Local Institution - 0315
ACTIVE_NOT_RECRUITING
Koto
Local Institution - 0328
ACTIVE_NOT_RECRUITING
Kurashiki
Local Institution - 0292
ACTIVE_NOT_RECRUITING
Kurume
Local Institution - 0319
ACTIVE_NOT_RECRUITING
Matsuyama
Local Institution - 0314
ACTIVE_NOT_RECRUITING
Ōsaka-sayama
Local Institution - 0313
ACTIVE_NOT_RECRUITING
Sapporo
Local Institution - 0291
ACTIVE_NOT_RECRUITING
Sendai
Local Institution - 0325
COMPLETED
Takatsuki
Local Institution - 0316
COMPLETED
Yokohama
Malaysia
Hospital Kuala Lumpur
RECRUITING
Kuala Lumpur
Local Institution - 0312
COMPLETED
Kuala Lumpur
Local Institution - 0311
ACTIVE_NOT_RECRUITING
Kuching
Mexico
Local Institution - 0146
ACTIVE_NOT_RECRUITING
Guadalajara
Local Institution - 0145
ACTIVE_NOT_RECRUITING
Puebla City
Netherlands
Local Institution - 0097
COMPLETED
Amsterdam
Local Institution - 0099
ACTIVE_NOT_RECRUITING
Arnhem
Local Institution - 0098
ACTIVE_NOT_RECRUITING
Groningen
Poland
Local Institution - 0195
ACTIVE_NOT_RECRUITING
Bydgoszcz
Local Institution - 0193
ACTIVE_NOT_RECRUITING
Konin
Local Institution - 0189
ACTIVE_NOT_RECRUITING
Lodz
Local Institution - 0241
ACTIVE_NOT_RECRUITING
Poznan
Local Institution - 0192
ACTIVE_NOT_RECRUITING
Prabuty
Republic of Korea
Local Institution - 0305
ACTIVE_NOT_RECRUITING
Cheongju-si
Local Institution - 0309
ACTIVE_NOT_RECRUITING
Daegu
Local Institution - 0286
ACTIVE_NOT_RECRUITING
Seongnam
Local Institution - 0285
ACTIVE_NOT_RECRUITING
Seoul
Local Institution - 0293
ACTIVE_NOT_RECRUITING
Seoul
Local Institution - 0304
ACTIVE_NOT_RECRUITING
Suwon
Romania
Local Institution - 0133
ACTIVE_NOT_RECRUITING
Bucharest
Local Institution - 0135
ACTIVE_NOT_RECRUITING
Bucharest
Local Institution - 0141
ACTIVE_NOT_RECRUITING
Cluj-napoca
Local Institution - 0140
ACTIVE_NOT_RECRUITING
Craiova
Local Institution - 0137
ACTIVE_NOT_RECRUITING
Florești
Institutul Regional de Oncologie
RECRUITING
Iași
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING
Iași
Spain
Local Institution - 0294
COMPLETED
Barcelona
Local Institution - 0302
ACTIVE_NOT_RECRUITING
Barcelona
Local Institution - 0301
ACTIVE_NOT_RECRUITING
Jaén
Local Institution - 0296
ACTIVE_NOT_RECRUITING
Madrid
Local Institution - 0298
ACTIVE_NOT_RECRUITING
Madrid
Local Institution - 0297
ACTIVE_NOT_RECRUITING
Majadahonda
Local Institution - 0300
ACTIVE_NOT_RECRUITING
Santiago De Compostela
Local Institution - 0295
ACTIVE_NOT_RECRUITING
Seville
Local Institution - 0299
ACTIVE_NOT_RECRUITING
Seville
Local Institution - 0303
ACTIVE_NOT_RECRUITING
Valencia
Switzerland
Local Institution - 0248
ACTIVE_NOT_RECRUITING
Chur
Local Institution - 0249
ACTIVE_NOT_RECRUITING
Winterthur
Local Institution - 0247
ACTIVE_NOT_RECRUITING
Zurich
Turkey
Local Institution - 0154
ACTIVE_NOT_RECRUITING
Adana
Local Institution - 0157
ACTIVE_NOT_RECRUITING
Ankara
Local Institution - 0177
ACTIVE_NOT_RECRUITING
Ankara
Local Institution - 0158
ACTIVE_NOT_RECRUITING
Çiğli
Local Institution - 0153
ACTIVE_NOT_RECRUITING
Istanbul
United Kingdom
Local Institution - 0159
COMPLETED
Aberdeen
Local Institution - 0183
COMPLETED
Central Middlesbrough
Local Institution - 0101
ACTIVE_NOT_RECRUITING
Manchester
Local Institution - 0226
ACTIVE_NOT_RECRUITING
Metropolitan Borough Of Wirral
Contact Information
Primary
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Clinical.Trials@bms.com
855-907-3286
Backup
First line of the email MUST contain NCT # and Site #.
Time Frame
Start Date: 2025-02-25
Estimated Completion Date: 2031-09-05
Participants
Target number of participants: 530
Treatments
Experimental: Arm A
Active_comparator: Arm B
Related Therapeutic Areas
Sponsors
Leads: Bristol-Myers Squibb