Small Cell Lung Cancer (SCLC) Clinical Trials

• The patient must be aged between 18 and 75 years (inclusive of boundary values), and both males and females are eligible.

• Pathologically confirmed LS-SCLC

• Investigator confirmation of at least one measurable lesion, as defined by RECIST v1.1

• ECOG performance status of 0 or 1

• Forced expiratory volume in one second (FEV₁) \> 1.0 L

• No clinically significant interstitial lung disease on baseline CT or PET/CT.

• Adequate organ and bone-marrow function (all tests performed within 7 days prior to first dose; no transfusions, growth factors, albumin, or other corrective therapies within 14 days):Hemoglobin ≥ 90 g/L, ANC ≥ 1.5 × 10⁹/L, PLT ≥ 90 × 10⁹/L,Serum creatinine ≤ 1.5 × ULN, TBIL ≤ 1.5 × ULN, ALT and AST ≤ 3 × ULN, Albumin (ALB) ≥ 25 g/L,INR ≤ 1.5 × ULN, PT and APTT ≤ 1.5 × ULN (subjects on prophylactic anticoagulation must have values within a safe therapeutic range, per investigator)

• Women of childbearing potential must have a negative serum or urine pregnancy test within 7 days prior to enrollment and agree to use reliable contraception from screening until 3 months after the last dose; male subjects must agree to use effective contraception or have undergone surgical sterilization for the same period.

• No prior systemic anti-tumor therapy before enrollment.

⁃ Estimated life expectancy ≥ 12 weeks.