• Age between 18 and 75 years old inclusive, at the time of signing the informed consent, regardless of gender.

• Weight ≥ 50 kg.

• Subjects with unilateral hemiplegia due to stroke (with a time interval of ≥ 3 months from stroke onset to randomized enrollment) exhibiting upper limb spasticity.

• Subjects with Disability Assessment Scale score of at least 2 on the Principal Target of Treatment (one of four functional domains: hygiene, dressing, limb position and pain).

• If taking oral antispasticity, the dosage must be stable for at least 1 month prior to randomized enrollment.

• If the study limb receives physical therapy or occupational therapy, the frequency, type, and intensity must be stable for at least 3 weeks prior to randomized enrollment.