• ≥18 years or minimum legal age as required by local regulations.

• Documented stable or unstable angina, positive functional test, or non -ST elevation myocardial infarction which, in the judgment of the operator, is attributable to disease in coronary vessel or in-stent restenosis, and the patient is deemed an appropriate candidate for PCI in accordance with the applicable guidelines on percutaneous coronary intervention.

• Note: participants with NSTEMI must have enzymes that are trending down or are within normal limits prior to enrollment.

• Life expectancy \>1 year in the Investigator's opinion.

• Participant is willing and able to cooperate with study procedures and follow-up evaluations.

• Treatment of only one target lesion required

‣ Tandem lesions treated by a single DCB will be considered one target lesion.

⁃ Up to one de novo lesion in a separate vessel may be treated per standard of care at the procedure. Non-target lesions must be successfully treated under the same criteria of the target lesion, before treating the target lesion.

• Target lesion must be ≤36 mm in length.

• Target lesion must have a stenosis ≥ 50% and \< 100%.

• Target lesion must have a visually estimated reference vessel diameter of:

‣ ISR lesions: 2.0 to 4.0 mm in diameter (inclusive)

⁃ de novo lesions: 2.0 to \<3.0 mm in diameter

• ISR lesions only: target lesion must be within a previous BMS or DES that does not extend \>5.0 mm beyond the proximal or distal edge.