Ora Secunda Cerclage Laser Retinopexy To Prevent Retinal Detachment In Stickler Syndrome (OSC/SS): A Prospective Historically Controlled Study
The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults. Researchers will compare the OSC/SS procedure in SS to the natural progression of SS to see to what extent the OSC/SS procedure works to prevent retinal detachment. Participants will: * Have the OSC/SS procedure in one or both eyes * Have eye tests * Have genetic testing for SS as needed * Visit the study center 9 times over 5 years for checkups and tests * Have data for the untreated fellow-eye collected and used as study data if available
• No contraindications to laser retinopexy surgery per local site criteria.
• Capable of giving signed informed consent, and assent (as appropriate)
• Signature of research informed consent form from participant, or participant's legally authorized representative (LAR)/parent(s)/legal guardian
• Male or female of any age
• SS type 1 or type 2 confirmed by genetic testing