A Prospective, Multicentre, Double-blind Randomized Controlled Clinical Study of the Efficacy and Safety of Taurine Combined With Serplulimab and Chemotherapy Versus Serplulimab Combined With Chemotherapy for Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Status: Recruiting
Location: See all (15) locations...
Intervention Type: Biological, Dietary supplement, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This project aims to evaluate the efficacy and safety of oral taurine supplementation combined with PD-1 inhibitor (serplulimab) and chemotherapy in inducing systemic CD8+ T cell responses and achieving improved gastric cancer patient outcomes than with serplulimab and chemotherapy alone.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age 18-75 years old, no gender limitation;
• Pathologically confirmed gastric or gastroesophageal junction adenocarcinoma with cTNM stage II/III，T≥3, N ≥0, M=0；
• Expected survival of ≥ 3 months;
• The tumor specimens were PD-L1 positive (CPS ≥ 1)；
• There is a measurable lesion with the possibility of radical R0 resection after evaluation by doctors；
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1;
• Patients informed about the purpose and course of the study and provided a written consent to participate.
Locations
Other Locations
China
The Third People's Hospital of Chengdu
RECRUITING
Chengdu
Army Specialty Medical Center of PLA (Daping Hospital)
RECRUITING
Chongqing
The First Affiliated Hospital of Army Medical University (Southwest Hospital)
RECRUITING
Chongqing
The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
RECRUITING
Chongqing
Affiliated Drum Tower Hospital, Medical School of Nanjing University
RECRUITING
Nanjing
Fudan University Shanghai Cancer Center (FUSCC)
RECRUITING
Shanghai
The First Affiliated Hospital of China Medical University
RECRUITING
Shenyang
Cancer Hospital Affiliated to Xinjiang Medical University
RECRUITING
Ürümqi
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
RECRUITING
Wuhan
Shaanxi Provincial People's Hospital
RECRUITING
Xi'an
Tang-Du Hospital
RECRUITING
Xi'an
The Second Affilated Hospital Of Xi'an Jiaotong University (Xibei Hospital)