Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 5
Maximum Age: 16
Healthy Volunteers: t
View:
• \- Children aged 5-16 years
Locations
Other Locations
Nepal
National Academy od Medical Sciences
RECRUITING
Kathmandu
Zambia
Centre of Infectious Disease Research
RECRUITING
Lusaka
Contact Information
Primary
Thomas Pilgrim Bern University Hospital, Bern, Switzerland
thomas.pilgrim@insel.ch
+41 31 632 08 27
Time Frame
Start Date: 2024-12-15
Estimated Completion Date: 2028-02
Participants
Target number of participants: 6000
Treatments
Experimental: School nurse program
The experimental intervention consists in a school nurse program providing integrated health care through diagnosis, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.
No_intervention: Standard of care
No school nurse prorgam.
Related Therapeutic Areas
Sponsors
Collaborators: University of Oxford, Centre for Infectious Disease Research in Zambia (CIDRZ), National Academy of Medical Sciences, Nepal
Leads: Thomas Pilgrim