The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark: an Open-Label, Pragmatic, Randomised Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice. Eligible participants are adults (≥18 years) presenting in general practice with symptoms of an acute LRTI (i.e., acute illness (≤ 21 days) usually with cough and minimum one other symptom such as dyspnea, sputum production, wheezing, chest discomfort or fever) in whom the GP finds it relevant to treat with antibiotics. Consenting patients who meet all the eligibility criteria will be randomised (1:1:1:1:1) to either three, four, five, six or seven days of treatment with phenoxymethylpenicillin 1.2 MIE four times daily.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Eligible participants are adults (≥18 years) presenting in general practice with symptoms of an acute LRTI (i.e., acute illness (≤ 21 days) usually with cough and minimum one other symptom such as dyspnoea, sputum production, wheezing, chest discomfort or fever) in whom the GP finds it relevant to treat with antibiotics.

Locations
Other Locations
Denmark
The Research Unit for General Practice Aalborg
RECRUITING
Gistrup
Contact Information
Primary
Eskild Johansen, MD, Ph.d.-student
ejoha@dcm.aau.dk
+45 31 58 29 13
Backup
Malene Plejdrup Hansen, MD, Associate Professor
mph@dcm.aau.dk
Time Frame
Start Date: 2023-11-13
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 600
Treatments
Experimental: 3 days
3 days of treatment with phenoxymethylpenicillin 1.2 MIE 4 times daily.
Experimental: 4 days
4 days of treatment with phenoxymethylpenicillin 1.2 MIE 4 times daily.
Experimental: 5 days
5 days of treatment with phenoxymethylpenicillin 1.2 MIE 4 times daily.
Experimental: 6 days
6 days of treatment with phenoxymethylpenicillin 1.2 MIE 4 times daily.
Active_comparator: 7 days
7 days of treatment with phenoxymethylpenicillin 1.2 MIE 4 times daily.
Related Therapeutic Areas
Sponsors
Leads: Research Unit for General Practice in Aalborg

This content was sourced from clinicaltrials.gov