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Mechanisms of Dynamic Airway Resistance Monitoring and Machine Learning for Assessing Pulmonary Inflammation and Guiding Sputum Suction in Mechanically Ventilated Patients

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \[10\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Clinical diagnosis of Acute Respiratory Distress Syndrome (ARDS)

• Clinical diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

• Clinical diagnosis of Severe pneumonia

Locations
Other Locations
China
Peking Union Medical College Hospital
RECRUITING
Beijing
The First Affiliated Hospital of Bengbu Medical University
RECRUITING
Bengbu
the Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING
Hangzhou
Contact Information
Primary
Hong-lei Wu Nursing Department, MS
wu_honglei@163.com
+8613862749927
Backup
xuan Qian Nursing Department, MS
1660694568@qq.com
+8615162763676
Time Frame
Start Date: 2025-10-30
Estimated Completion Date: 2029-12-30
Participants
Target number of participants: 258
Treatments
Experimental: Airway resistance-guided sputum suction
Investigators will continuously monitor the airway viscous resistance of patients, and initiate suctioning when the airway viscous resistance increases by ≥6 cmH₂O.
No_intervention: conventional suctioning
In the control group, the decision to suction was made based on conventional clinical signs, including rhonchi and a rise in peak pressure.
Related Therapeutic Areas
Sponsors
Leads: Affiliated Hospital of Nantong University

This content was sourced from clinicaltrials.gov