Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage (SAH): a Prospective Observational Study
Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Adult
• patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage
Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Other Locations
Italy
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING
Rome
Contact Information
Primary
Lorenzo Berra, MD
lberra@mgh.harvard.edu
617-726-3030
Time Frame
Start Date: 2024-03-03
Estimated Completion Date: 2027-06
Participants
Target number of participants: 40
Treatments
Aneurysmal subarachnoid hemorrhage
Patients admitted to the Intensive Care Unit following spontaneous aneurysmal subarachnoid hemorrhage
Control
Patients without neurological comorbidities undergoing spinal anesthesia in the operating room
Related Therapeutic Areas
Sponsors
Collaborators: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Leads: Massachusetts General Hospital