Pilot Study of Linezolid for Early Syphilis Treatment
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: f
View:
• 16 years of age or older
• Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
• Able to provide informed consent
• For PLHIV: on treatment for HIV-infection and most recent viral load \<200 copies/mL or most recent CD4 T-cell count \>350 cells/mL
Locations
United States
Illinois
Howard Brown Health
RECRUITING
Chicago
Mississippi
Open Arms HealthCare Center
RECRUITING
Jackson
Contact Information
Primary
Jeffrey D Klausner, MD MPH
jdklausner@med.usc.edu
(415) 876-8901
Time Frame
Start Date: 2023-09-28
Estimated Completion Date: 2026-03
Participants
Target number of participants: 24
Treatments
Experimental: Linezolid 10 Day
Oral linezolid 600mg, taken twice a day for 10 days
Active_comparator: Benzathine Penicillin G
Single intramuscular injection of 2.4 million units of benzathine penicillin G
Related Therapeutic Areas
Sponsors
Collaborators: The University of Texas Health Science Center, Houston, Universidad Peruana Cayetano Heredia
Leads: University of Southern California