Pilot Study of Linezolid for Early Syphilis Treatment
Status: Active_not_recruiting
Location: See all (5) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: f
View:
• Diagnosed cases of primary, secondary or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
• 16 years of age or older
• Able to provide informed consent/assent.
• Individuals with HIV infection must be on treatment for HIV-infection and virologically suppressed (viral load \< 200 copies/mL) or have a CD4 count ≥ 350 cells/mm3 as of their most recent test prior to enrollment.
Locations
United States
Illinois
Howard Brown Health
Chicago
Mississippi
Open Arms HealthCare Center
Jackson
University of Mississippi Medical Center
Jackson
North Carolina
Wake Forest Baptist Health
Greensboro
Rhode Island
Open Door Health
Providence
Time Frame
Start Date: 2023-09-28
Completion Date: 2026-08
Participants
Target number of participants: 24
Treatments
Experimental: Linezolid 10 Day
Oral linezolid 600mg, taken twice a day for 10 days
Active_comparator: Benzathine Penicillin G
Single intramuscular injection of 2.4 million units of benzathine penicillin G
Related Therapeutic Areas
Sponsors
Leads: University of Southern California