• Male or female participant, aged 18 to 65 years (inclusive), at time of consent

• BMI greater than or equal to 18 and less than 39 kg/m2 at Screening

• Diagnosis of SLE at least 6 months prior to Screening

• Minimal to moderate SLE disease activity

• If a participant is taking oral prednisone, the dose must be less than or equal to 20 mg/day for a minimum of 8 weeks prior to Screening and at a stable dose for a minimum of 2 weeks prior to Screening

• If a participant is taking azathioprine, antimalarial, mycophenolate mofetil, or methotrexate, the medication(s) must have been started a minimum of 12 weeks prior to Screening and at a stable dose for a minimum of 8 weeks prior to Screening