Systemic Sclerosis (SSc)
Symptoms, Doctors, Treatments, Advances & More

Systemic Sclerosis (SSc) Overview

Save information for later
Sign Up

Learn About Systemic Sclerosis (SSc)

What is the definition of Systemic Sclerosis (SSc)?
Systemic sclerosis, also called scleroderma, is an autoimmune disorder that cause the skin to tighten and harden. Systemic sclerosis can also affect the blood vessels, digestive tract, and internal organs.
What are the symptoms of Systemic Sclerosis (SSc)?
Systemic sclerosis can be localized, limited, or spread more widely (diffuse). Symptoms of systemic sclerosis include hardening and tightening of the skin; skin thickening; skin swelling; itchiness; skin discoloration; red spots; calcium deposits under the skin; pale, blue, red, painful, or numb fingers and toes (Raynaud’s syndrome); heartburn; difficulty swallowing; bloating; diarrhea; constipation; fecal incontinence; dizziness; shortness of breath; high blood pressure; pulmonary hypertension; swelling in the legs and feet; irregular heartbeat; and heart failure.
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Systemic Sclerosis (SSc)?
There is currently no cure for systemic sclerosis. Treatment for systemic sclerosis includes medications such as vasodilators, immunosuppressants, antacids, antibiotics, and pain relievers; physical or occupational therapies; stem cell transplants; and organ transplantation.
Who are the top Systemic Sclerosis (SSc) Local Doctors?
Elite in Systemic Sclerosis (SSc)
Elite in Systemic Sclerosis (SSc)
Referral required

Riverside Rheumatology Specialists Williamsburg

120 Kings Way, 2700, 
Williamsburg, VA 
757-221-0110
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Chase Correia is a Rheumatologist practicing medicine in Williamsburg, Virginia. Dr. Correia is rated as an Elite provider by MediFind in the treatment of Systemic Sclerosis (SSc). He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Scleroderma, Systemic Sclerosis (SSc), Scleroma, and Necrotizing Vasculitis. Dr. Correia is board certified in American Board Of Internal Medicine - Rheumatology and American Board Of Internal Medicine - Internal Medicine.

Elite in Systemic Sclerosis (SSc)
Dr. Robyn T. Domsic
Rheumatology
Elite in Systemic Sclerosis (SSc)
Dr. Robyn T. Domsic
Rheumatology
Referral may be required
Before you request

UPMC St. Margaret Rheumatology

200 Delafield Road, St Margaret Medical Arts Bldg, Suite 4040, 
Pittsburgh, PA 
412-784-1466
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Robyn Domsic is a Rheumatologist practicing medicine in Pittsburgh, Pennsylvania. Dr. Domsic is rated as an Elite provider by MediFind in the treatment of Systemic Sclerosis (SSc). She is also highly rated in 9 other conditions, according to our data. Her clinical expertise encompasses Scleroderma, Systemic Sclerosis (SSc), Raynaud Phenomenon, and Scleroma. Dr. Domsic is board certified in American Board Of Internal Medicine. Dr. Domsic is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Systemic Sclerosis (SSc)
Elite in Systemic Sclerosis (SSc)
Referral may be required
Before you request
6410 Fannin St, Ste 450, 
Houston, TX 
713-486-3100
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Maureen Mayes is a Rheumatologist practicing medicine in Houston, Texas. Dr. Mayes is rated as an Elite provider by MediFind in the treatment of Systemic Sclerosis (SSc). She is also highly rated in 7 other conditions, according to our data. Her clinical expertise encompasses Scleroderma, Systemic Sclerosis (SSc), Scleroma, and Localized Scleroderma. Dr. Mayes is currently accepting new patients.

View All Doctors
What are the latest Systemic Sclerosis (SSc) Clinical Trials?
A Two-part, Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single-ascending-dose Study of PRO-203 in Healthy Adult Volunteers Followed by an Open-label, Single-ascending-dose With Priming Study of PRO-203 in Participants With Systemic Sclerosis
A Two-part, Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single-ascending-dose Study of PRO-203 in Healthy Adult Volunteers Followed by an Open-label, Single-ascending-dose With Priming Study of PRO-203 in Participants With Systemic Sclerosis
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Drug, Other
Study Phase: Phase 1/Phase 2

Summary: A two-part study of PRO-203 administered subcutaneously in healthy adult volunteers and participants with Systemic Sclerosis (SSc).

Match to trials
Find the right clinical trials for you in under a minute
Get started
A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate The Efficacy And Safety of Belimumab Administered Subcutaneously in Adults With Systemic Sclerosis Associated Interstitial Lung Disease (SSC-ILD)
A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate The Efficacy And Safety of Belimumab Administered Subcutaneously in Adults With Systemic Sclerosis Associated Interstitial Lung Disease (SSC-ILD)
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Other, Biological
Study Phase: Phase 2/Phase 3

Summary: This study investigates the efficacy and safety of belimumab compared to placebo, in addition to standard therapy, for the treatment of participants with systemic sclerosis associated interstitial lung disease (SSc-ILD). The study will evaluate the effect of belimumab treatment on lung function as well as on extra-pulmonary disease manifestations, including skin thickening and general symptoms, su...

View All Clinical Trials