A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors

Who is this study for? Patients with Tumor, Teratoma
Status: Recruiting
Location: See all (629) locations...
Intervention Type: Other, Procedure, Biological, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• There is no age limit for the low risk stratum (stage I ovarian immature teratoma and stage I non-seminoma or seminoma malignant GCT \[all sites\])

• Standard risk 1: Patients must be \< 11 years of age at enrollment

• Standard risk 2: Patients must be \>= 11 and \< 25 years of age at enrollment

• Patients enrolling on one of the low risk arms must be newly diagnosed with a stage I germ cell tumor; for the standard risk arms, patients must be newly diagnosed with malignant germ cell tumor (stage II or higher).

‣ Histologic confirmation of a primary extracranial germ cell tumor in any of the categories outlined below is required of all patients at enrollment , with the following exceptions:

• Among patients were initially diagnosed with completely resected non-seminoma malignant GCT and later recur during observation post surgery, a diagnostic biopsy is not required for enrollment if elevated tumor markers rise to \> 5 x upper limit of normal (ULN) on at least 2 measurements taken at least 1 week apart. The pathology report of initial surgery should be provided

∙ Patients may be enrolled without histologic or cytologic confirmation in the rare case where there are exceptionally raised tumor markers (alpha fetoprotein \[AFP- ≥ 500 ng/mL or HCG ≥ 500 IU/L) and radiologic features consistent with GCT. In addition, the treating clinician must deem that the patient's tumor is not suitable for upfront resection and that a biopsy is not in the patient's best interest; or that there is a need to start therapy urgently

• Low risk immature teratoma (IT); site: ovarian; stage: any; grade: any; histology: pure immature teratoma, mixed immature and mature teratoma, (may contain microscopic foci of yolk sac tumor \[\< 3 mm\], but no other pathological evidence of MGCT); tumor markers: alpha-FP =\< 1,000 ng/mL, beta-HCG institutional normal; all ages

• Low risk stage I non-seminoma MGCT; site: ovarian, testicular, or extragonadal; stage: COG stage I, FIGO stage IA and IB, American Joint Committee on Cancer (AJCC) testicular stage IA, IB and IS; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma (pure or mixed); all ages

• Low risk stage I seminoma-MGCT; site: testicular; stage: COG stage I; AJCC testicular stage IA IB, and IS; histology: must contain only seminoma; may contain immature/mature teratoma; may NOT contain yolk sac tumor, embryonal carcinoma, or choriocarcinoma; all ages

• Standard risk 1 (SR1); site: ovarian, testicular, or extragonadal; stage: COG stage II-IV, FIGO stage IC-IV, (International Germ Cell Consensus Classification \[IGCCC\] criteria DO NOT apply); histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \< 11

• Standard risk 2 (SR2)

‣ Site: ovarian; stage: COG stage II, III, and III-X, FIGO stage IC, II and III; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \>= 11 and \< 25

⁃ Site: testicular; stage: COG stage II-IV, AJCC stage II, III, IGCCC good risk; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma: must be IGCCC good risk; post op: alpha-FP \< 1,000 ng/mL, beta-HCG \< 5,000 IU/mL and lactate dehydrogenase (LDH) \< 3.0 x normal; age (years) \>= 11 and \< 25

• Notes:

‣ IGCCC criteria only apply to SR2 patients with a testicular primary tumor

⁃ Use post-op tumor marker levels to determine IGCCC risk group

⁃ Pure seminoma patients are not eligible for the standard risk arms of the study

⁃ For the low risk stage I non-seminoma MGCT and the standard risk arms, components of yolk sac tumor, embryonal carcinoma, or choriocarcinoma can be mixed with other forms of GCT, such as seminoma or mature or immature teratoma; if yolk sac tumor is the only malignant component present, then it must be deemed by the pathologist to be greater than a microscopic component of yolk sac tumor

• Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, 2 or 3; use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age

• Organ function requirements apply ONLY to patients who will receive chemotherapy (SR1 and SR2 patients)

• Adequate renal function defined as:

• Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 (within 7 days prior to enrollment) OR

• A serum creatinine based on age/sex as follows (within 7 days prior to enrollment): (mg/dL)

‣ 1 month to \< 6 months male: 0.4 female: 0.4

⁃ 6 months to \< 1 year male: 0.5 female: 0.5

⁃ 1 to \< 2 years male: 0.6 female: 0.6

⁃ \>= 16 years male: 1.7 female: 1.4

• Total bilirubin =\< 2 x upper limit of normal (ULN) for age (within 7 days prior to enrollment)

‣ Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome

• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 3 x upper limit of normal (ULN) (within 7 days prior to enrollment)

‣ Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome

• Peripheral absolute neutrophil count (ANC) \>= 750/mm\^3 (within 7 days prior to enrollment) AND

• Platelet count \>= 75,000/mm\^3 (within 7 days prior to enrollment)

• Patients enrolling on the standard risk arms must be medically fit to receive protocol treatment and with no contraindications to protocol treatment

• Eligibility criteria to participate in the pilot study of the AYA-Hears instrument (patient reported outcomes \[PROs\] of ototoxicity) Note: participants in group 1 will not receive AGCT1531 protocol-directed therapy; all other AYA-HEARS patients must be enrolled on the AGCT1531 SR2 arm in order to participate

• \>= 11 and \< 25 years old at enrollment

• Able to fluently speak and read English

• Has received prior cisplatin- or carboplatin-based chemotherapy regimen for malignancy including diagnoses other than germ cell tumor

• Followed for cancer or survivorship care at one of the following institutions:

‣ Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

⁃ Dana Farber/Harvard Cancer Center

⁃ Hospital for Sick Children

⁃ Children's Hospital of Eastern Ontario

⁃ Oregon Health and Science University

⁃ Seattle Children's Hospital

⁃ Yale University

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
RECRUITING
Anchorage
Alaska Oncology and Hematology LLC
RECRUITING
Anchorage
Alaska Women's Cancer Care
RECRUITING
Anchorage
Anchorage Associates in Radiation Medicine
RECRUITING
Anchorage
Anchorage Oncology Centre
SUSPENDED
Anchorage
Anchorage Radiation Therapy Center
SUSPENDED
Anchorage
Katmai Oncology Group
RECRUITING
Anchorage
Providence Alaska Medical Center
RECRUITING
Anchorage
Alabama
Children's Hospital of Alabama
RECRUITING
Birmingham
USA Health Strada Patient Care Center
RECRUITING
Mobile
Arkansas
CHI Saint Vincent Cancer Center Hot Springs
SUSPENDED
Hot Springs
Arkansas Children's Hospital
RECRUITING
Little Rock
CARTI Cancer Center
RECRUITING
Little Rock
University of Arkansas for Medical Sciences
ACTIVE_NOT_RECRUITING
Little Rock
Arizona
Kingman Regional Medical Center
RECRUITING
Kingman
Banner Children's at Desert
RECRUITING
Mesa
Cancer Center at Saint Joseph's
ACTIVE_NOT_RECRUITING
Phoenix
Phoenix Childrens Hospital
RECRUITING
Phoenix
Banner University Medical Center - Tucson
ACTIVE_NOT_RECRUITING
Tucson
University of Arizona Cancer Center-North Campus
ACTIVE_NOT_RECRUITING
Tucson
California
Kaiser Permanente-Anaheim
RECRUITING
Anaheim
Mission Hope Medical Oncology - Arroyo Grande
ACTIVE_NOT_RECRUITING
Arroyo Grande
PCR Oncology
RECRUITING
Arroyo Grande
Kaiser Permanente-Bellflower
RECRUITING
Bellflower
Providence Saint Joseph Medical Center/Disney Family Cancer Center
RECRUITING
Burbank
Mercy Cancer Center - Carmichael
ACTIVE_NOT_RECRUITING
Carmichael
Mercy San Juan Medical Center
ACTIVE_NOT_RECRUITING
Carmichael
Kaiser Permanente Downey Medical Center
RECRUITING
Downey
City of Hope Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING
Duarte
Mercy Cancer Center - Elk Grove
ACTIVE_NOT_RECRUITING
Elk Grove
Kaiser Permanente-Fontana
RECRUITING
Fontana
UC San Diego Moores Cancer Center
RECRUITING
La Jolla
Loma Linda University Medical Center
RECRUITING
Loma Linda
Miller Children's and Women's Hospital Long Beach
RECRUITING
Long Beach
Cedars Sinai Medical Center
RECRUITING
Los Angeles
Children's Hospital Los Angeles
RECRUITING
Los Angeles
Kaiser Permanente Los Angeles Medical Center
RECRUITING
Los Angeles
Los Angeles General Medical Center
ACTIVE_NOT_RECRUITING
Los Angeles
Mattel Children's Hospital UCLA
RECRUITING
Los Angeles
UCLA / Jonsson Comprehensive Cancer Center
SUSPENDED
Los Angeles
USC / Norris Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING
Los Angeles
Valley Children's Hospital
RECRUITING
Madera
Providence Queen of The Valley
RECRUITING
Napa
USC Norris Oncology/Hematology-Newport Beach
ACTIVE_NOT_RECRUITING
Newport Beach
Kaiser Permanente-Oakland
RECRUITING
Oakland
UCSF Benioff Children's Hospital Oakland
RECRUITING
Oakland
Children's Hospital of Orange County
RECRUITING
Orange
Lucile Packard Children's Hospital Stanford University
RECRUITING
Palo Alto
Stanford Cancer Institute Palo Alto
SUSPENDED
Palo Alto
Mercy Cancer Center - Rocklin
ACTIVE_NOT_RECRUITING
Rocklin
Kaiser Permanente-Roseville
ACTIVE_NOT_RECRUITING
Roseville
Mercy Cancer Center - Sacramento
ACTIVE_NOT_RECRUITING
Sacramento
Sutter Medical Center Sacramento
ACTIVE_NOT_RECRUITING
Sacramento
University of California Davis Comprehensive Cancer Center
RECRUITING
Sacramento
Kaiser Permanente-San Diego Mission
RECRUITING
San Diego
Naval Medical Center -San Diego
RECRUITING
San Diego
Rady Children's Hospital - San Diego
RECRUITING
San Diego
UCSF Medical Center-Mission Bay
RECRUITING
San Francisco
Pacific Central Coast Health Center-San Luis Obispo
ACTIVE_NOT_RECRUITING
San Luis Obispo
Kaiser Permanente Medical Center - Santa Clara
ACTIVE_NOT_RECRUITING
Santa Clara
Mission Hope Medical Oncology - Santa Maria
ACTIVE_NOT_RECRUITING
Santa Maria
Providence Medical Foundation - Santa Rosa
RECRUITING
Santa Rosa
Providence Santa Rosa Memorial Hospital
RECRUITING
Santa Rosa
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
ACTIVE_NOT_RECRUITING
Torrance
Woodland Memorial Hospital
ACTIVE_NOT_RECRUITING
Woodland
Colorado
Children's Hospital Colorado
RECRUITING
Aurora
UCHealth University of Colorado Hospital
ACTIVE_NOT_RECRUITING
Aurora
Memorial Hospital North
ACTIVE_NOT_RECRUITING
Colorado Springs
Penrose-Saint Francis Healthcare
ACTIVE_NOT_RECRUITING
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
ACTIVE_NOT_RECRUITING
Colorado Springs
Saint Francis Cancer Center
ACTIVE_NOT_RECRUITING
Colorado Springs
UCHealth Memorial Hospital Central
ACTIVE_NOT_RECRUITING
Colorado Springs
AdventHealth Porter
ACTIVE_NOT_RECRUITING
Denver
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
RECRUITING
Denver
CommonSpirit Cancer Center Mercy
ACTIVE_NOT_RECRUITING
Durango
Mercy Medical Center
ACTIVE_NOT_RECRUITING
Durango
Cancer Care and Hematology-Fort Collins
ACTIVE_NOT_RECRUITING
Fort Collins
Poudre Valley Hospital
ACTIVE_NOT_RECRUITING
Fort Collins
Mountain Blue Cancer Care Center
SUSPENDED
Golden
UCHealth Greeley Hospital
ACTIVE_NOT_RECRUITING
Greeley
Rocky Mountain Cancer Centers-Lakewood
SUSPENDED
Lakewood
Saint Anthony Hospital
ACTIVE_NOT_RECRUITING
Lakewood
AdventHealth Littleton
ACTIVE_NOT_RECRUITING
Littleton
UCHealth Lone Tree Health Center
ACTIVE_NOT_RECRUITING
Lone Tree
Longmont United Hospital
ACTIVE_NOT_RECRUITING
Longmont
Rocky Mountain Cancer Centers-Longmont
SUSPENDED
Longmont
Medical Center of the Rockies
ACTIVE_NOT_RECRUITING
Loveland
AdventHealth Parker
ACTIVE_NOT_RECRUITING
Parker
Rocky Mountain Cancer Centers-Parker
SUSPENDED
Parker
Rocky Mountain Cancer Centers - Pueblo
SUSPENDED
Pueblo
Saint Mary Corwin Medical Center
ACTIVE_NOT_RECRUITING
Pueblo
Rocky Mountain Cancer Centers-Thornton
SUSPENDED
Thornton
Connecticut
Connecticut Children's Medical Center
RECRUITING
Hartford
Yale University
RECRUITING
New Haven
Washington, D.c.
Children's National Medical Center
RECRUITING
Washington D.c.
Kaiser Permanente-Capitol Hill Medical Center
SUSPENDED
Washington D.c.
MedStar Georgetown University Hospital
ACTIVE_NOT_RECRUITING
Washington D.c.
Delaware
Alfred I duPont Hospital for Children
RECRUITING
Wilmington
Florida
Broward Health Medical Center
RECRUITING
Fort Lauderdale
Golisano Children's Hospital of Southwest Florida
RECRUITING
Fort Myers
University of Florida Health Science Center - Gainesville
RECRUITING
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING
Hollywood
Nemours Children's Clinic-Jacksonville
RECRUITING
Jacksonville
Miami Cancer Institute
RECRUITING
Miami
Nicklaus Children's Hospital
RECRUITING
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING
Miami
AdventHealth Orlando
RECRUITING
Orlando
Arnold Palmer Hospital for Children
RECRUITING
Orlando
Nemours Children's Hospital
RECRUITING
Orlando
Nemours Children's Clinic - Pensacola
RECRUITING
Pensacola
Sacred Heart Hospital
SUSPENDED
Pensacola
Johns Hopkins All Children's Hospital
RECRUITING
St. Petersburg
Saint Joseph's Hospital/Children's Hospital-Tampa
RECRUITING
Tampa
Tampa General Hospital
RECRUITING
Tampa
Saint Mary's Medical Center
RECRUITING
West Palm Beach
Georgia
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING
Atlanta
Augusta University Medical Center
RECRUITING
Augusta
Atrium Health Navicent
RECRUITING
Macon
Memorial Health University Medical Center
RECRUITING
Savannah
Hawaii
Kaiser Permanente Moanalua Medical Center
SUSPENDED
Honolulu
Kapiolani Medical Center for Women and Children
RECRUITING
Honolulu
Straub Clinic and Hospital
RECRUITING
Honolulu
Tripler Army Medical Center
ACTIVE_NOT_RECRUITING
Honolulu
Iowa
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING
Ankeny
Mercy Cancer Center-West Lakes
RECRUITING
Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING
Clive
Alegent Health Mercy Hospital
ACTIVE_NOT_RECRUITING
Council Bluffs
Greater Regional Medical Center
RECRUITING
Creston
Blank Children's Hospital
RECRUITING
Des Moines
Iowa Lutheran Hospital
SUSPENDED
Des Moines
Iowa Methodist Medical Center
RECRUITING
Des Moines
Mercy Medical Center - Des Moines
RECRUITING
Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING
Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING
Des Moines
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING
Iowa City
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING
Waukee
Mercy Medical Center-West Lakes
RECRUITING
West Des Moines
The Iowa Clinic PC
RECRUITING
West Des Moines
Idaho
Saint Luke's Cancer Institute - Boise
RECRUITING
Boise
Saint Luke's Cancer Institute - Fruitland
RECRUITING
Fruitland
Saint Luke's Cancer Institute - Meridian
RECRUITING
Meridian
Saint Luke's Cancer Institute - Nampa
RECRUITING
Nampa
Saint Luke's Cancer Institute - Twin Falls
RECRUITING
Twin Falls
Illinois
Rush-Copley Medical Center
ACTIVE_NOT_RECRUITING
Aurora
Illinois CancerCare-Bloomington
RECRUITING
Bloomington
Illinois CancerCare-Canton
RECRUITING
Canton
Memorial Hospital of Carbondale
RECRUITING
Carbondale
SIH Cancer Institute
RECRUITING
Carterville
Illinois CancerCare-Carthage
RECRUITING
Carthage
Centralia Oncology Clinic
RECRUITING
Centralia
John H Stroger Jr Hospital of Cook County
SUSPENDED
Chicago
Lurie Children's Hospital-Chicago
RECRUITING
Chicago
Rush University Medical Center
SUSPENDED
Chicago
University of Chicago Comprehensive Cancer Center
RECRUITING
Chicago
University of Illinois
RECRUITING
Chicago
Carle at The Riverfront
ACTIVE_NOT_RECRUITING
Danville
Cancer Care Specialists of Illinois - Decatur
RECRUITING
Decatur
Decatur Memorial Hospital
RECRUITING
Decatur
Illinois CancerCare-Dixon
RECRUITING
Dixon
Carle Physician Group-Effingham
ACTIVE_NOT_RECRUITING
Effingham
Crossroads Cancer Center
RECRUITING
Effingham
Illinois CancerCare-Eureka
RECRUITING
Eureka
NorthShore University HealthSystem-Evanston Hospital
RECRUITING
Evanston
Illinois CancerCare-Galesburg
RECRUITING
Galesburg
Western Illinois Cancer Treatment Center
SUSPENDED
Galesburg
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING
Glenview
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING
Highland Park
Illinois CancerCare-Kewanee Clinic
RECRUITING
Kewanee
Illinois CancerCare-Macomb
RECRUITING
Macomb
Carle Physician Group-Mattoon/Charleston
ACTIVE_NOT_RECRUITING
Mattoon
Loyola University Medical Center
ACTIVE_NOT_RECRUITING
Maywood
Cancer Care Center of O'Fallon
SUSPENDED
O'fallon
HSHS Saint Elizabeth's Hospital
RECRUITING
O'fallon
Advocate Children's Hospital-Oak Lawn
RECRUITING
Oak Lawn
Illinois CancerCare-Ottawa Clinic
RECRUITING
Ottawa
Advocate Children's Hospital-Park Ridge
RECRUITING
Park Ridge
Illinois CancerCare-Pekin
RECRUITING
Pekin
OSF Saint Francis Radiation Oncology at Pekin
RECRUITING
Pekin
Illinois CancerCare-Peoria
RECRUITING
Peoria
Methodist Medical Center of Illinois
RECRUITING
Peoria
OSF Saint Francis Medical Center
SUSPENDED
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
RECRUITING
Peoria
Saint Jude Midwest Affiliate
RECRUITING
Peoria
Illinois CancerCare-Peru
RECRUITING
Peru
Valley Radiation Oncology
RECRUITING
Peru
Illinois CancerCare-Princeton
RECRUITING
Princeton
North Shore Medical Center
SUSPENDED
Skokie
Saint John's Hospital
RECRUITING
Springfield
Southern Illinois University School of Medicine
RECRUITING
Springfield
Springfield Clinic
RECRUITING
Springfield
Springfield Memorial Hospital
SUSPENDED
Springfield
Southwest Illinois Health Services LLP
SUSPENDED
Swansea
Carle Cancer Center
ACTIVE_NOT_RECRUITING
Urbana
The Carle Foundation Hospital
ACTIVE_NOT_RECRUITING
Urbana
Illinois CancerCare - Washington
RECRUITING
Washington
Rush-Copley Healthcare Center
ACTIVE_NOT_RECRUITING
Yorkville
Indiana
IU Health North Hospital
SUSPENDED
Carmel
Deaconess Clinic Downtown
ACTIVE_NOT_RECRUITING
Evansville
Ascension Saint Vincent Indianapolis Hospital
RECRUITING
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
ACTIVE_NOT_RECRUITING
Indianapolis
Riley Hospital for Children
RECRUITING
Indianapolis
Chancellor Center for Oncology
ACTIVE_NOT_RECRUITING
Newburgh
Memorial Hospital of South Bend
SUSPENDED
South Bend
Kansas
Wesley Medical Center
RECRUITING
Wichita
Kentucky
Flaget Memorial Hospital
ACTIVE_NOT_RECRUITING
Bardstown
Commonwealth Cancer Center-Corbin
ACTIVE_NOT_RECRUITING
Corbin
Saint Joseph Hospital
ACTIVE_NOT_RECRUITING
Lexington
Saint Joseph Hospital East
ACTIVE_NOT_RECRUITING
Lexington
Saint Joseph Radiation Oncology Resource Center
ACTIVE_NOT_RECRUITING
Lexington
University of Kentucky/Markey Cancer Center
RECRUITING
Lexington
Saint Joseph London
ACTIVE_NOT_RECRUITING
London
Jewish Hospital
SUSPENDED
Louisville
Norton Children's Hospital
RECRUITING
Louisville
Saints Mary and Elizabeth Hospital
SUSPENDED
Louisville
UofL Health Medical Center Northeast
SUSPENDED
Louisville
Saint Joseph Mount Sterling
ACTIVE_NOT_RECRUITING
Mount Sterling
Jewish Hospital Medical Center South
ACTIVE_NOT_RECRUITING
Shepherdsville
Louisiana
Children's Hospital New Orleans
RECRUITING
New Orleans
Ochsner Medical Center Jefferson
RECRUITING
New Orleans
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Massachusetts General Hospital Cancer Center
RECRUITING
Boston
Tufts Children's Hospital
SUSPENDED
Boston
Tufts Medical Center
RECRUITING
Boston
Baystate Medical Center
RECRUITING
Springfield
UMass Memorial Medical Center - University Campus
RECRUITING
Worcester
Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING
Baltimore
Sinai Hospital of Baltimore
RECRUITING
Baltimore
University of Maryland/Greenebaum Cancer Center
RECRUITING
Baltimore
Walter Reed National Military Medical Center
RECRUITING
Bethesda
Maine
Eastern Maine Medical Center
RECRUITING
Bangor
Lafayette Family Cancer Center-EMMC
ACTIVE_NOT_RECRUITING
Brewer
MaineHealth Maine Medical Center - Portland
RECRUITING
Portland
Maine Children's Cancer Program
RECRUITING
Scarborough
MaineHealth Maine Medical Center- Scarborough
RECRUITING
Scarborough
Michigan
C S Mott Children's Hospital
RECRUITING
Ann Arbor
University of Michigan Comprehensive Cancer Center
RECRUITING
Ann Arbor
Bronson Battle Creek
RECRUITING
Battle Creek
Children's Hospital of Michigan
RECRUITING
Detroit
Henry Ford Health Saint John Hospital
ACTIVE_NOT_RECRUITING
Detroit
Michigan State University
ACTIVE_NOT_RECRUITING
East Lansing
OSF Saint Francis Hospital and Medical Group
ACTIVE_NOT_RECRUITING
Escanaba
Hurley Medical Center
ACTIVE_NOT_RECRUITING
Flint
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING
Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING
Grand Rapids
Trinity Health Grand Rapids Hospital
RECRUITING
Grand Rapids
Beacon Kalamazoo
RECRUITING
Kalamazoo
Bronson Methodist Hospital
RECRUITING
Kalamazoo
West Michigan Cancer Center
RECRUITING
Kalamazoo
Trinity Health Muskegon Hospital
RECRUITING
Muskegon
Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING
Niles
Lake Huron Medical Center
SUSPENDED
Port Huron
Corewell Health Reed City Hospital
RECRUITING
Reed City
Corewell Health Children's
RECRUITING
Royal Oak
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING
Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
RECRUITING
Saint Joseph
Munson Medical Center
RECRUITING
Traverse City
University of Michigan Health - West
RECRUITING
Wyoming
Minnesota
Essentia Health Cancer Center
ACTIVE_NOT_RECRUITING
Duluth
Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITING
Minneapolis
University of Minnesota/Masonic Cancer Center
RECRUITING
Minneapolis
Mayo Clinic in Rochester
RECRUITING
Rochester
Missouri
Parkland Health Center-Bonne Terre
SUSPENDED
Bonne Terre
Mercy Cancer Center - Cape Girardeau
RECRUITING
Cape Girardeau
Saint Francis Medical Center
RECRUITING
Cape Girardeau
University of Missouri Children's Hospital
RECRUITING
Columbia
Parkland Health Center - Farmington
RECRUITING
Farmington
MU Health Care Goldschmidt Cancer Center
SUSPENDED
Jefferson City
Children's Mercy Hospitals and Clinics
RECRUITING
Kansas City
Lake Regional Hospital
RECRUITING
Osage Beach
Sainte Genevieve County Memorial Hospital
RECRUITING
Sainte Genevieve
Mercy Hospital Saint Louis
RECRUITING
St Louis
Missouri Baptist Medical Center
RECRUITING
St Louis
Washington University School of Medicine
RECRUITING
St Louis
Missouri Baptist Sullivan Hospital
RECRUITING
Sullivan
BJC Outpatient Center at Sunset Hills
RECRUITING
Sunset Hills
Mississippi
University of Mississippi Medical Center
RECRUITING
Jackson
Montana
Saint Patrick Hospital - Community Hospital
RECRUITING
Missoula
North Carolina
Mission Hospital
RECRUITING
Asheville
UNC Lineberger Comprehensive Cancer Center
RECRUITING
Chapel Hill
Carolinas Medical Center/Levine Cancer Institute
RECRUITING
Charlotte
Novant Health Presbyterian Medical Center
RECRUITING
Charlotte
Oncology Specialists of Charlotte
SUSPENDED
Charlotte
Southern Oncology Specialists-Charlotte
SUSPENDED
Charlotte
Southeastern Medical Oncology Center-Clinton
RECRUITING
Clinton
Duke University Medical Center
RECRUITING
Durham
Southeastern Medical Oncology Center-Goldsboro
RECRUITING
Goldsboro
Wayne Memorial Hospital
ACTIVE_NOT_RECRUITING
Goldsboro
East Carolina University
RECRUITING
Greenville
Novant Health Cancer Institute - Huntersville
SUSPENDED
Huntersville
Southern Oncology Specialists-Huntersville
SUSPENDED
Huntersville
Southeastern Medical Oncology Center-Jacksonville
RECRUITING
Jacksonville
Matthews Radiation Oncology Center
SUSPENDED
Matthews
Novant Health Cancer Institute - Matthews
SUSPENDED
Matthews
Novant Health Cancer Institute - Mooresville
SUSPENDED
Mooresville
Novant Health Cancer Institute - Rowan
SUSPENDED
Salisbury
Rowan Regional Medical Center
SUSPENDED
Salisbury
Wake Forest University Health Sciences
RECRUITING
Winston-salem
North Dakota
Sanford Broadway Medical Center
RECRUITING
Fargo
Nebraska
Nebraska Cancer Specialists/Oncology Hematology West PC
SUSPENDED
Grand Island
CHI Health Good Samaritan
ACTIVE_NOT_RECRUITING
Kearney
Fred and Pamela Buffett Cancer Center - Kearney
SUSPENDED
Kearney
Saint Elizabeth Regional Medical Center
ACTIVE_NOT_RECRUITING
Lincoln
Alegent Health Bergan Mercy Medical Center
ACTIVE_NOT_RECRUITING
Omaha
Alegent Health Immanuel Medical Center
ACTIVE_NOT_RECRUITING
Omaha
Alegent Health Lakeside Hospital
ACTIVE_NOT_RECRUITING
Omaha
Children's Hospital and Medical Center of Omaha
RECRUITING
Omaha
Creighton University Medical Center
ACTIVE_NOT_RECRUITING
Omaha
Hematology and Oncology Consultants PC
SUSPENDED
Omaha
University of Nebraska Medical Center
RECRUITING
Omaha
Midlands Community Hospital
ACTIVE_NOT_RECRUITING
Papillion
New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING
Lebanon
New Jersey
Hackensack University Medical Center
RECRUITING
Hackensack
Morristown Medical Center
RECRUITING
Morristown
Jersey Shore Medical Center
RECRUITING
Neptune City
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
RECRUITING
New Brunswick
Saint Peter's University Hospital
RECRUITING
New Brunswick
Newark Beth Israel Medical Center
RECRUITING
Newark
Saint Joseph's Regional Medical Center
RECRUITING
Paterson
New Mexico
Presbyterian Hospital
RECRUITING
Albuquerque
University of New Mexico Cancer Center
RECRUITING
Albuquerque
Nevada
Carson Tahoe Regional Medical Center
RECRUITING
Carson City
Cancer and Blood Specialists-Henderson
SUSPENDED
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
RECRUITING
Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge
RECRUITING
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
RECRUITING
Henderson
Las Vegas Cancer Center-Henderson
SUSPENDED
Henderson
Las Vegas Urology - Green Valley
RECRUITING
Henderson
Las Vegas Urology - Pebble
RECRUITING
Henderson
OptumCare Cancer Care at Seven Hills
RECRUITING
Henderson
Urology Specialists of Nevada - Green Valley
RECRUITING
Henderson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
RECRUITING
Las Vegas
Ann M Wierman MD LTD
RECRUITING
Las Vegas
Cancer and Blood Specialists-Shadow
SUSPENDED
Las Vegas
Cancer and Blood Specialists-Tenaya
SUSPENDED
Las Vegas
Cancer Therapy and Integrative Medicine
SUSPENDED
Las Vegas
Comprehensive Cancer Centers of Nevada
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center
RECRUITING
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
RECRUITING
Las Vegas
Desert West Surgery
SUSPENDED
Las Vegas
Hope Cancer Care of Nevada
RECRUITING
Las Vegas
Las Vegas Cancer Center-Medical Center
SUSPENDED
Las Vegas
Las Vegas Urology - Cathedral Rock
RECRUITING
Las Vegas
Las Vegas Urology - Pecos
RECRUITING
Las Vegas
Las Vegas Urology - Smoke Ranch
RECRUITING
Las Vegas
Las Vegas Urology - Sunset
RECRUITING
Las Vegas
OptumCare Cancer Care at Charleston
RECRUITING
Las Vegas
OptumCare Cancer Care at Fort Apache
RECRUITING
Las Vegas
OptumCare Cancer Care at MountainView
RECRUITING
Las Vegas
Radiation Oncology Centers of Nevada Central
RECRUITING
Las Vegas
Radiation Oncology Centers of Nevada Southeast
RECRUITING
Las Vegas
Summerlin Hospital Medical Center
RECRUITING
Las Vegas
Sunrise Hospital and Medical Center
RECRUITING
Las Vegas
University Cancer Center
SUSPENDED
Las Vegas
University Medical Center of Southern Nevada
RECRUITING
Las Vegas
Urology Specialists of Nevada - Central
RECRUITING
Las Vegas
Urology Specialists of Nevada - Northwest
RECRUITING
Las Vegas
Urology Specialists of Nevada - Southwest
RECRUITING
Las Vegas
Women's Cancer Center of Nevada
RECRUITING
Las Vegas
Hope Cancer Care of Nevada-Pahrump
RECRUITING
Pahrump
Cancer Care Specialists - Reno
SUSPENDED
Reno
Radiation Oncology Associates
RECRUITING
Reno
Renown Regional Medical Center
RECRUITING
Reno
Saint Mary's Regional Medical Center
RECRUITING
Reno
New York
Albany Medical Center
RECRUITING
Albany
Maimonides Medical Center
RECRUITING
Brooklyn
Roswell Park Cancer Institute
RECRUITING
Buffalo
Glens Falls Hospital
ACTIVE_NOT_RECRUITING
Glens Falls
NYU Langone Hospital - Long Island
RECRUITING
Mineola
The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITING
New Hyde Park
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING
New York
Memorial Sloan Kettering Cancer Center
RECRUITING
New York
Mount Sinai Hospital
RECRUITING
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING
New York
University of Rochester
ACTIVE_NOT_RECRUITING
Rochester
Stony Brook University Medical Center
RECRUITING
Stony Brook
State University of New York Upstate Medical University
RECRUITING
Syracuse
Children's Hospital at Montefiore
RECRUITING
The Bronx
Montefiore Medical Center - Moses Campus
RECRUITING
The Bronx
Montefiore Medical Center-Einstein Campus
RECRUITING
The Bronx
Montefiore Medical Center-Weiler Hospital
RECRUITING
The Bronx
New York Medical College
RECRUITING
Valhalla
Westchester Medical Center
RECRUITING
Valhalla
Ohio
Children's Hospital Medical Center of Akron
RECRUITING
Akron
OhioHealth O'Bleness Hospital
RECRUITING
Athens
Strecker Cancer Center-Belpre
RECRUITING
Belpre
Adena Regional Medical Center
RECRUITING
Chillicothe
Bethesda North Hospital
ACTIVE_NOT_RECRUITING
Cincinnati
Cincinnati Children's Hospital Medical Center
RECRUITING
Cincinnati
Good Samaritan Hospital - Cincinnati
ACTIVE_NOT_RECRUITING
Cincinnati
TriHealth Cancer Institute-Anderson
ACTIVE_NOT_RECRUITING
Cincinnati
TriHealth Cancer Institute-Westside
ACTIVE_NOT_RECRUITING
Cincinnati
Case Western Reserve University
RECRUITING
Cleveland
Cleveland Clinic Foundation
RECRUITING
Cleveland
Rainbow Babies and Childrens Hospital
RECRUITING
Cleveland
Columbus Oncology and Hematology Associates Inc
RECRUITING
Columbus
Doctors Hospital
RECRUITING
Columbus
Grant Medical Center
RECRUITING
Columbus
Mount Carmel East Hospital
RECRUITING
Columbus
Mount Carmel Health Center West
RECRUITING
Columbus
Nationwide Children's Hospital
RECRUITING
Columbus
Ohio State University Comprehensive Cancer Center
RECRUITING
Columbus
Riverside Methodist Hospital
RECRUITING
Columbus
The Mark H Zangmeister Center
RECRUITING
Columbus
Dayton Children's Hospital
RECRUITING
Dayton
Delaware Health Center-Grady Cancer Center
RECRUITING
Delaware
Grady Memorial Hospital
RECRUITING
Delaware
Columbus Oncology and Hematology Associates
RECRUITING
Dublin
Dublin Methodist Hospital
RECRUITING
Dublin
Mount Carmel Grove City Hospital
RECRUITING
Grove City
Saint Rita's Medical Center
RECRUITING
Lima
OhioHealth Mansfield Hospital
RECRUITING
Mansfield
Marietta Memorial Hospital
RECRUITING
Marietta
OhioHealth Marion General Hospital
RECRUITING
Marion
Memorial Hospital
RECRUITING
Marysville
Knox Community Hospital
RECRUITING
Mount Vernon
Licking Memorial Hospital
RECRUITING
Newark
Mercy Health - Perrysburg Hospital
RECRUITING
Perrysburg
OhioHealth Pickerington Methodist Hospital
RECRUITING
Pickerington
Southern Ohio Medical Center
RECRUITING
Portsmouth
ProMedica Flower Hospital
RECRUITING
Sylvania
Mercy Health - Saint Anne Hospital
RECRUITING
Toledo
Mercy Health - Saint Vincent Hospital
RECRUITING
Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
RECRUITING
Toledo
OhioHealth Westerville Medical Campus/Westerville Cancer Center
RECRUITING
Westerville
Saint Ann's Hospital
RECRUITING
Westerville
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
RECRUITING
Wilmington
Genesis Healthcare System Cancer Care Center
RECRUITING
Zanesville
Oklahoma
Cancer Centers of Southwest Oklahoma Research
RECRUITING
Lawton
University of Oklahoma Health Sciences Center
RECRUITING
Oklahoma City
Oregon
Saint Charles Health System
RECRUITING
Bend
Clackamas Radiation Oncology Center
RECRUITING
Clackamas
Providence Cancer Institute Clackamas Clinic
SUSPENDED
Clackamas
Bay Area Hospital
RECRUITING
Coos Bay
Asante Rogue Regional Medical Center
SUSPENDED
Medford
Providence Newberg Medical Center
RECRUITING
Newberg
Providence Willamette Falls Medical Center
RECRUITING
Oregon City
Legacy Emanuel Children's Hospital
RECRUITING
Portland
Oregon Health and Science University
RECRUITING
Portland
Providence Portland Medical Center
RECRUITING
Portland
Providence Saint Vincent Medical Center
RECRUITING
Portland
Pennsylvania
Jefferson Abington Hospital
ACTIVE_NOT_RECRUITING
Abington
Lehigh Valley Hospital-Cedar Crest
RECRUITING
Allentown
Lehigh Valley Hospital - Muhlenberg
SUSPENDED
Bethlehem
Geisinger Medical Center
RECRUITING
Danville
Penn State Children's Hospital
RECRUITING
Hershey
Children's Hospital of Philadelphia
RECRUITING
Philadelphia
Saint Christopher's Hospital for Children
RECRUITING
Philadelphia
University of Pennsylvania/Abramson Cancer Center
RECRUITING
Philadelphia
Children's Hospital of Pittsburgh of UPMC
RECRUITING
Pittsburgh
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING
Pittsburgh
UPMC-Magee Womens Hospital
RECRUITING
Pittsburgh
UPMC-Passavant Hospital
RECRUITING
Pittsburgh
Asplundh Cancer Pavilion
ACTIVE_NOT_RECRUITING
Willow Grove
Rhode Island
Rhode Island Hospital
RECRUITING
Providence
South Carolina
Prisma Health Cancer Institute - Spartanburg
RECRUITING
Boiling Springs
Medical University of South Carolina
RECRUITING
Charleston
Prisma Health Richland Hospital
RECRUITING
Columbia
Gibbs Cancer Center-Gaffney
RECRUITING
Gaffney
BI-LO Charities Children's Cancer Center
RECRUITING
Greenville
Prisma Health Cancer Institute - Butternut
RECRUITING
Greenville
Prisma Health Cancer Institute - Eastside
RECRUITING
Greenville
Prisma Health Cancer Institute - Faris
RECRUITING
Greenville
Prisma Health Greenville Memorial Hospital
SUSPENDED
Greenville
Saint Francis Cancer Center
RECRUITING
Greenville
Saint Francis Hospital
RECRUITING
Greenville
Gibbs Cancer Center-Pelham
RECRUITING
Greer
Prisma Health Cancer Institute - Greer
RECRUITING
Greer
Prisma Health Cancer Institute - Seneca
RECRUITING
Seneca
North Grove Medical Park
RECRUITING
Spartanburg
Spartanburg Medical Center
RECRUITING
Spartanburg
Spartanburg Medical Center - Mary Black Campus
RECRUITING
Spartanburg
SMC Center for Hematology Oncology Union
RECRUITING
Union
South Dakota
Sanford USD Medical Center - Sioux Falls
RECRUITING
Sioux Falls
Tennessee
Memorial Hospital
SUSPENDED
Chattanooga
T C Thompson Children's Hospital
RECRUITING
Chattanooga
Pulmonary Medicine Center of Chattanooga-Hixson
SUSPENDED
Hixson
East Tennessee Childrens Hospital
RECRUITING
Knoxville
Saint Jude Children's Research Hospital
RECRUITING
Memphis
The Children's Hospital at TriStar Centennial
RECRUITING
Nashville
Vanderbilt University/Ingram Cancer Center
RECRUITING
Nashville
Memorial GYN Plus
SUSPENDED
Ooltewah
Texas
Texas Tech University Health Sciences Center-Amarillo
RECRUITING
Amarillo
The Don and Sybil Harrington Cancer Center
SUSPENDED
Amarillo
Dell Children's Medical Center of Central Texas
RECRUITING
Austin
Saint Joseph Regional Cancer Center
ACTIVE_NOT_RECRUITING
Bryan
Driscoll Children's Hospital
RECRUITING
Corpus Christi
Medical City Dallas Hospital
RECRUITING
Dallas
Parkland Memorial Hospital
SUSPENDED
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING
Dallas
El Paso Children's Hospital
RECRUITING
El Paso
Texas Tech University Health Sciences Center-El Paso
SUSPENDED
El Paso
Cook Children's Medical Center
RECRUITING
Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING
Houston
M D Anderson Cancer Center
RECRUITING
Houston
Covenant Children's Hospital
RECRUITING
Lubbock
Texas Tech University Health Sciences Center-Lubbock
ACTIVE_NOT_RECRUITING
Lubbock
UMC Cancer Center / UMC Health System
RECRUITING
Lubbock
Children's Hospital of San Antonio
RECRUITING
San Antonio
Methodist Children's Hospital of South Texas
RECRUITING
San Antonio
University Hospital
RECRUITING
San Antonio
University of Texas Health Science Center at San Antonio
RECRUITING
San Antonio
Scott and White Memorial Hospital
RECRUITING
Temple
Utah
Primary Children's Hospital
RECRUITING
Salt Lake City
Virginia
University of Virginia Cancer Center
RECRUITING
Charlottesville
Children's Hospital of The King's Daughters
RECRUITING
Norfolk
Naval Medical Center - Portsmouth
RECRUITING
Portsmouth
VCU Massey Comprehensive Cancer Center
RECRUITING
Richmond
Carilion Children's
RECRUITING
Roanoke
Vermont
Central Vermont Medical Center/National Life Cancer Treatment
ACTIVE_NOT_RECRUITING
Berlin Corners
University of Vermont and State Agricultural College
RECRUITING
Burlington
University of Vermont Medical Center
ACTIVE_NOT_RECRUITING
Burlington
Washington
Providence Regional Cancer System-Aberdeen
RECRUITING
Aberdeen
Overlake Medical Center
SUSPENDED
Bellevue
PeaceHealth Saint Joseph Medical Center
RECRUITING
Bellingham
Highline Medical Center-Main Campus
ACTIVE_NOT_RECRUITING
Burien
Providence Regional Cancer System-Centralia
RECRUITING
Centralia
Swedish Cancer Institute-Edmonds
RECRUITING
Edmonds
Saint Elizabeth Hospital
ACTIVE_NOT_RECRUITING
Enumclaw
Providence Regional Cancer Partnership
RECRUITING
Everett
Saint Francis Hospital
ACTIVE_NOT_RECRUITING
Federal Way
Swedish Cancer Institute-Issaquah
RECRUITING
Issaquah
Kadlec Clinic Hematology and Oncology
RECRUITING
Kennewick
Providence Regional Cancer System-Lacey
RECRUITING
Lacey
Saint Clare Hospital
ACTIVE_NOT_RECRUITING
Lakewood
PeaceHealth Saint John Medical Center
RECRUITING
Longview
Harrison HealthPartners Hematology and Oncology-Poulsbo
ACTIVE_NOT_RECRUITING
Poulsbo
Kaiser Permanente Washington
ACTIVE_NOT_RECRUITING
Seattle
Pacific Gynecology Specialists
SUSPENDED
Seattle
Seattle Children's Hospital
RECRUITING
Seattle
Swedish Medical Center-Ballard Campus
RECRUITING
Seattle
Swedish Medical Center-Cherry Hill
RECRUITING
Seattle
Swedish Medical Center-First Hill
RECRUITING
Seattle
Providence Regional Cancer System-Shelton
SUSPENDED
Shelton
Saint Michael Cancer Center
ACTIVE_NOT_RECRUITING
Silverdale
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
SUSPENDED
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - North
SUSPENDED
Spokane
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
SUSPENDED
Spokane Valley
Franciscan Research Center-Northwest Medical Plaza
ACTIVE_NOT_RECRUITING
Tacoma
Madigan Army Medical Center
RECRUITING
Tacoma
Mary Bridge Children's Hospital and Health Center
RECRUITING
Tacoma
Northwest Medical Specialties PLLC
SUSPENDED
Tacoma
PeaceHealth Southwest Medical Center
SUSPENDED
Vancouver
Providence Saint Mary Regional Cancer Center
RECRUITING
Walla Walla
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
RECRUITING
Yakima
Providence Regional Cancer System-Yelm
SUSPENDED
Yelm
Wisconsin
Green Bay Oncology at Saint Vincent Hospital
RECRUITING
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING
Green Bay
University of Wisconsin Carbone Cancer Center - Johnson Creek
SUSPENDED
Johnson Creek
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING
Madison
Holy Family Memorial Hospital
SUSPENDED
Manitowoc
Saint Vincent Hospital Cancer Center at Marinette
SUSPENDED
Marinette
Marshfield Medical Center-Marshfield
SUSPENDED
Marshfield
Children's Hospital of Wisconsin
RECRUITING
Milwaukee
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING
Oconto Falls
HSHS Saint Nicholas Hospital
RECRUITING
Sheboygan
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING
Sturgeon Bay
West Virginia
United Hospital Center
SUSPENDED
Bridgeport
West Virginia University Charleston Division
RECRUITING
Charleston
Edwards Comprehensive Cancer Center
RECRUITING
Huntington
WVUH-Berkely Medical Center
SUSPENDED
Martinsburg
West Virginia University Healthcare
RECRUITING
Morgantown
Camden Clark Medical Center
SUSPENDED
Parkersburg
Other Locations
Australia
Monash Medical Center-Clayton Campus
RECRUITING
Clayton
John Hunter Children's Hospital
RECRUITING
Hunter Regional Mail Centre
Royal Children's Hospital
RECRUITING
Parkville
Perth Children's Hospital
RECRUITING
Perth
Princess Margaret Hospital for Children
ACTIVE_NOT_RECRUITING
Perth
Sydney Children's Hospital
RECRUITING
Randwick
Queensland Children's Hospital
RECRUITING
South Brisbane
The Children's Hospital at Westmead
RECRUITING
Westmead
Canada
Alberta Children's Hospital
RECRUITING
Calgary
University of Alberta Hospital
RECRUITING
Edmonton
IWK Health Centre
RECRUITING
Halifax
McMaster Children's Hospital at Hamilton Health Sciences
RECRUITING
Hamilton
Kingston Health Sciences Centre
RECRUITING
Kingston
Children's Hospital
RECRUITING
London
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING
Montreal
The Montreal Children's Hospital of the MUHC
RECRUITING
Montreal
Children's Hospital of Eastern Ontario
RECRUITING
Ottawa
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
SUSPENDED
Québec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING
Sherbrooke
Janeway Child Health Centre
RECRUITING
St. John's
Hospital for Sick Children
RECRUITING
Toronto
Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITING
Toronto
University Health Network-Princess Margaret Hospital
RECRUITING
Toronto
British Columbia Children's Hospital
RECRUITING
Vancouver
CancerCare Manitoba
RECRUITING
Winnipeg
India
Tata Memorial Hospital
SUSPENDED
Mumbai
Japan
Chiba University
RECRUITING
Chiba-sgi
Saitama Children's Medical Center
RECRUITING
Chuo-ku
Kyushu Univeristy
RECRUITING
Higashiku
Hiroshima University Hospital
RECRUITING
Hiroshima
Hyogo Prefectural Kobe Children's Hospital
RECRUITING
Kobe
Kyoto Perfectural University of Medicine
RECRUITING
Kyoto
Niigata Cancer Centre
RECRUITING
Niigata
Hyogo College of Medicine
SUSPENDED
Nishinomiya, Hyogo
Osaka City General Hospital
SUSPENDED
Osaka
Saitama Medical University International Medical Center
RECRUITING
Saitama
Hokkaido University Hospital
RECRUITING
Sapporo
Tohoku University School of Medicine
RECRUITING
Sendai
Keio University
RECRUITING
Shinjuku-ku
Kokuritsu Seiiku Medical Research Center Hospital
RECRUITING
Tokyo
National Cancer Center Hospital
RECRUITING
Tokyo
University of Tsukuba Hospital
RECRUITING
Tsukuba
Kanagawa Children's Medical Center
RECRUITING
Yokohama
New Zealand
Christchurch Hospital
RECRUITING
Christchurch
Starship Children's Hospital
RECRUITING
Grafton
Puerto Rico
HIMA San Pablo Oncologic Hospital
ACTIVE_NOT_RECRUITING
Caguas
San Jorge Children's Hospital
ACTIVE_NOT_RECRUITING
San Juan
Saudi Arabia
King Faisal Specialist Hospital and Research Centre
RECRUITING
Riyadh
United Kingdom
Sheffield Children's Hospital
RECRUITING
Broomhall
Addenbrookes Hospital-Medical School
RECRUITING
Cambridge
Royal Hospital for Children and Young People
RECRUITING
Edinburgh
Western General Hospital
RECRUITING
Edinburgh
Beatson Oncology Center
RECRUITING
Glasgow
Royal Hospital for Children
RECRUITING
Glasgow
Saint Bartholomew's Hospital
RECRUITING
London
University College London Hospitals NHS Trust - Foley Street
RECRUITING
London
Royal Manchester Children Hospital
RECRUITING
Manchester
Royal Victoria Infirmary
RECRUITING
Newcastle
Freeman Hospital
RECRUITING
Newcastle Upon Tyne
John Radcliffe Hospital
RECRUITING
Oxford
Weston Park Hospital
RECRUITING
Sheffield
Leeds General Infirmary
RECRUITING
West Yorkshire
Saint James's University Hospital
RECRUITING
West Yorkshire
Time Frame
Start Date: 2017-05-25
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 1780
Treatments
Experimental: Arm I (bleomycin, carboplatin, etoposide)
Patients receive bleomycin IV over 10 minutes and carboplatin IV over 1 hour on day 1. Patients also receive etoposide IV over 1-2 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.
Experimental: Arm II (bleomycin, etoposide, cisplatin)
Patients receive bleomycin IV over 10 minutes on day 1. Patients also receive etoposide IV over 1-2 hours and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.
Experimental: Arm III (bleomycin, etoposide, carboplatin)
Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.
Experimental: Arm IV (bleomycin, etoposide, cisplatin)
Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.
Experimental: Low-Risk (observation)
Patients with low-risk stage I grade 2, 3 ovarian immature teratoma or stage I non-seminoma or seminoma MGCTs undergo observation and can transfer to standard risk arm when eligibility criteria are met. Patients with stage I seminoma testicular MGCT undergo observation, and those with residual/recurrent disease are treated at the discretion of their physician. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial.
Authors
Thomas W. McLean, Kathleen J. Yost, Lisa L. Hartman, Angela R. Girvin, Haydar A. Frangoul, Nina S. Kadan-Lottick, Corina E. Gonzalez, Kristin K. Zorn, Archana Sharma, Anna B. Pawlowska, Douglas S. Hawkins, Eduard H. Panosyan, Vinod K. Gidvani-Diaz, Luis A. Clavell, Matthew A. Kutny, Rene Y. McNall-Knapp, Eric J. Lowe, Mary L. Schmidt, William A. May, Gary D. Crouch, Nadine P. SantaCruz, Mariko Sato, Caroline Y. Hu, Ashok B. Raj, Mark S. Shahin, John J. Gregory, Jessica Boklan, Lisa Gennarini, Stanton C. Goldman, Karen S. Fernandez, John J. Letterio, Ziad A. Khatib, Mukund G. Dole, Laura E. Agresta, Adit L. Tal, Phillip E. Barnette, Rabi Hanna, Hardeo K. Panchoosingh, Timothy C. Griffin, Mehmet S. Copur, Robin D. Hanson, Vincent F. Giusti, Juan F. Rico, Jennifer A. Domm, William B. Slayton, Lolie C. Yu, Julia Glade-Bender, Mark J. Mogul, David E. Kram, Christopher P. Keuker, Kamnesh R. Pradhan, Aron Flagg, Holly E. Pariury, Pooja Hingorani, Felipe S. Bautista-Otanez, Peri Kamalakar, Ray C. Pais, Sheri L. Spunt, Adonis N. Lorenzana, Jason Law, Paul M. Barr, Emily C. McClung, Shelton A. Viola, Krishna C. Alluri, Felicia L. Wilson, Laura B. Huffman, Jhon A. Guerra, Michelle A. Manalang, Erlyn C. Smith, Nagesh H. Jayaram, Burton E. Appel, Aghiad Chamdin, Emily G. Greengard, Thomas B. Russell, Timothy D. Moore, Meghann P. McManus, Carla B. Golden, Priya Mahajan, Robert D. Siegel, Jonathan L. Metts, Minnie Abromowitch, Jean A. Hurteau, Kara-Marie H. Delaney, Ramamoorthy Nagasubramanian, Nichole L. Bryant, Santosh S. Hanmod, Wendy L. Woods-Swafford, Susan G. Kreissman, Jeffrey R. Andolina, Sara Chaffee, Philip M. Monteleone, Nabil Adra, Jeffrey A. Toretsky, Lauren M. Vasta, Guy H. Grayson, Brenda J. Wittman, Robert J. Hayashi, Yung S. Yim, Enrique A. Escalon, Dana A. Obzut, Nicholas G. Cost, Janice F. Olson, Steven J. Kuerbitz, Meghen B. Browning, James I. Geller, Mark E. Weinblatt, Susanna V. Ulahannan, Sharon L. Gardner, Julie Kim, Frank M. Balis, Anishka D'Souza, Pillai Pallavi Madhusoodhan, Steven L. Halpern, Anita Ravipati, Lydia A. Boateng, Stuart H. Gold, Lars M. Wagner, Eugene Suh, Vlad C. Radulescu, Samuel O. Anim, Bethany G. Sleckman, Benjamin B. Bridges, Linda C. Stork, Ranjan Bista, Yvan Samson, Douglas R. Strother, Vonda L. Crouse, Narayana Gowda, Sharon B. Abish, David B. Dix, Paul J. Wood, Jordan R. Hansford, Conrad V. Fernandez, Bruno Michon, Carol A. Portwine
Sponsors
Leads: Children's Oncology Group
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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