Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 9 months
Maximum Age: 2
Healthy Volunteers: t
View:
• Male or female individuals at the age of 9-24-month-old
• Must have at least one fully erupted tooth at baseline visit
• Parent/guardian willing and able to provide informed consent
• With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)
Locations
United States
Pennsylvania
Temple University
RECRUITING
Philadelphia
Contact Information
Primary
Yuan Liu, DDS, MS, PhD
yuan.liu0008@temple.edu
215-707-8029
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2028-08-31
Participants
Target number of participants: 70
Treatments
Children with history of OPC
Individuals in the non-OPC cohort will be age and sex-matched to individuals in the OPC cohort.
Children without history of OPC
Individuals in the OPC cohort will be age and sex-matched to individuals in the non-OPC cohort.
Related Therapeutic Areas
Sponsors
Leads: Temple University
Collaborators: Children's Hospital of Philadelphia