A Prospective Study of Hypofractionated Radiotherapy for Thymic Epithelial Tumors

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if hypofractionated radiotherapy works to shorten the treatment time without increasing the side effects in patients of thymic epithelial tumors. The main questions it aims to answer are: * Does Hypofractionated radiotherapy provide better results? * Can hypofractionated radiotherapy reduce toxic and side effects compared with conventional radiotherapy? Researchers will compare the efficacy and safety of hypofractionated radiotherapy after thymic tumor surgery. Participants will: * Receive hypofractionated radiotherapy or conventional radiotherapy * Visit the hospital regularly once every 12 weeks for checkups and tests

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
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• Patients must provide written informed consent.

• 18 years old ≤ age \<75 years old.

• Thymoma confirmed by pathology: type A, type AB, type B1, type B2, type B3. Thymic carcinoma. Patients with previous thymectomy were required to have complete surgical related data.

• Masaoka⁃Koga ⁃ stage Ⅰ-Ⅲ

• ECOG performance status 0-2.

• Expected survival time \> 1 year.

• Participants of childbearing age must agree to use effective contraception during the trial; In women of childbearing age, a serum or urine pregnancy test must be negative.

• Patients who are not lactating.

• Sufficient bone marrow reserve and good function of important organs.

Locations
Other Locations
China
Xiangya Hospital, Central South University
RECRUITING
Changsha
Contact Information
Primary
Rongrong Zhou, MD, PHD
zhourr@csu.edu.cn
+8613875898127
Time Frame
Start Date: 2024-10-01
Estimated Completion Date: 2027-11-01
Participants
Target number of participants: 100
Treatments
Experimental: Hypofractionated Radiotherapy
R0 resection: 42-48 Gy/14-16f or 40-44 Gy or 10-11f,40 Gy/8f R1 resection: 48-51 Gy/16-17f or 44-48 Gy/11-12f or 40-45 Gy/8-9f R2 resection: 51-60 Gy/17-20f or 48-56 Gy/12-14f or 45 -60Gy/9-12f
No_intervention: Conventional Radiotherapy
R0 resection: 45-50Gy/20-25f R1 resection: 54-56Gy/25-28f R2 resection: 60-70Gy/30-35f
Related Therapeutic Areas
Sponsors
Leads: Rongrong Zhou

This content was sourced from clinicaltrials.gov