The Effect of Bethanechol on Work of Breathing and Expiratory Tracheal Collapse in Infants With Tracheobronchomalacia Measured by Electrical Activity of the Diaphragm and Bronchoscopy
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
The primary aim of this study is to determine if work of breathing estimated using swing Edi will be improved following initiation of bethanechol in infants with tracheobronchomalacia. The investigators hypothesize that work of breathing will be improved in infants with tracheobronchomalacia estimated by a 20% mean decrease in swing Edi following initiation of bethanechol.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• Infants with a diagnosis of tracheobronchomalacia by dynamic computed tomography and showing \> 50% cross-sectional diameter collapse at 40 to 60 post menstrual age and for whom will be treatment with bethanechol in level IV center Neonatal Intensive Care Unit.
Locations
United States
Arkansas
Arkansas Children's Hospital
RECRUITING
Little Rock
Contact Information
Primary
Charles P Pugh, MD
cpugh2@uams.edu
9013352402
Backup
David Matlock, MD
dmatlock@uams.edu
3184589097
Time Frame
Start Date: 2022-08-11
Estimated Completion Date: 2024-06-30
Participants
Target number of participants: 20
Treatments
Infants with diagnosis of tracheobronchomalacia treated with bethanechol
Infants with a diagnosis of tracheobronchomalacia by dynamic computed tomography and showing \> 50% cross-sectional diameter collapse at 40 to 60 post menstrual age
Related Therapeutic Areas
Sponsors
Leads: Arkansas Children's Hospital Research Institute