Kebele Elimination of Trachoma for Ocular Health
Who is this study for? Patients with trachoma
What treatments are being studied? Azithromycin
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The investigators propose a cluster-randomized clinical trial to determine whether an intensive, targeted azithromycin distribution strategy is effective for elimination of trachoma at the kebele level compared to the World Health Organization (WHO) recommendation of annual azithromycin distribution.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• All individuals in all communities will be eligible for annual mass azithromycin distribution per WHO guidelines.
Locations
United States
California
UCSF Proctor Foundation
ACTIVE_NOT_RECRUITING
San Francisco
Other Locations
Ethiopia
Eyu-Ethiopia
RECRUITING
Bahir Dar
Contact Information
Primary
Tom M Lietman, MD
Tom.Lietman@ucsf.edu
415-502-2662
Backup
Hadley Burroughs, MSPH
Hadley.burroughs@ucsf.edu
415-476-1442
Time Frame
Start Date: 2022-02-07
Estimated Completion Date: 2028-03-01
Participants
Target number of participants: 320000
Treatments
Active_comparator: WHO-recommended
Annual mass azithromycin distribution of all residents
Experimental: Age-based core group
Annual mass azithromycin treatment of everyone plus quarterly treatment of children
Experimental: PCR infection-based core group
Annual mass azithromycin treatment plus quarterly treatment of a PCR-based cohort that would be a subset of the age-based core group.
Experimental: TI-based core group
Annual mass azithromycin treatment plus quarterly treatment of a conjunctival photography-based cohort that would be a subset of the age-based core group
Related Therapeutic Areas
Sponsors
Leads: University of California, San Francisco
Collaborators: Bahir Dar University, Eyu-Ethiopia, National Eye Institute (NEI)