Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors. The receptor blockade profile of a beta blocker can influence its physiological effects and potential therapeutic benefits in TBI. Therefore, the variation in receptor selectivity may result in differences in their impact on secondary brain injury processes and patient outcomes.
⁃ 1\. Patients with moderate \& severe TBI detected on admission by CT scan and GCS score of ≤ 13 who either do not have any other injuries or only have associated minor injuries.
⁃ Minor injuries are defined as presence of any of the following:
• Mild intraperitoneal free fluid (IPFF) observed through abdominal ultrasound.
• mild lung contusion detected in the chest CT scan.
• hemothorax or pneumothorax present without accompanying symptoms of hypoxia, tachypnea, or respiratory distress.
• simple limb fractures.