A Prospective, Multicenter, Parallel, Randomized Controlled Study to Evaluate the Safety and Effectiveness of the DragonFly-T Transcatheter Tricuspid Valve Clip System in the Treatment of Tricuspid Regurgitation

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The primary objective of this trial is to demonstrate the safety and effectiveness of the DragonFly-T system in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or greater estimated risk for mortality or morbidity with tricuspid valve surgery. This randomized controlled trial will compare the investigational device (DragonFly-T system) to Control (Medical Therapy).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years

• In the judgment of the local cardiac team, the patient has been adequately treated according to applicable standards (including medical management)and has been stable for at least 30 days.

• Despite the drug optimization treatment according to the above method, patients still have symptoms of TR;

• Determined by the local cardiac team to be at intermediate or higher risk for tricuspid valve surgery

• New York Heart Association (NYHA) Cardiac function Class II-IVa;

⁃ 5\. The patient is suitable for transcatheter tricuspid valve repair, suitable for the use of this study instrument, and the femoral vein access is feasible and can accommodate catheter; 6. Patient must provide written informed consent before any steps related to the study.

Locations
Other Locations
China
West China Hospital of Sichuan University
RECRUITING
Chengdu
The Second Affiliated Hospital Zhejiang University School of Medicine
RECRUITING
Hangzhou
Contact Information
Primary
Bo Liu
bo.liu@valgenmed.com
+8613001980902
Backup
Shuangjie Li
shuangjie.li@valgenmed.com
+8617756106609
Time Frame
Start Date: 2024-08-15
Estimated Completion Date: 2027-12-15
Participants
Target number of participants: 236
Treatments
Experimental: Randomized - Device Group
The experimental group is allocated to use a novel tricuspid valve repair system for edge-to-edge repair manufactured by Hangzhou Valgen Medtech Co., Ltd. and will continue to be managed on medical therapy, per physician discretion
Active_comparator: Randomized - Control Group
Subjects will continue to be managed on medical therapy, per physician discretion
Related Therapeutic Areas
Sponsors
Leads: Hangzhou Valgen Medtech Co., Ltd

This content was sourced from clinicaltrials.gov